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Publication Name World Journal of Clinical Cases
Manuscript ID 117692
Country Italy
Received
2025-12-15 01:26
Peer-Review Started
2025-12-15 01:26
First Decision by Editorial Office Director
2025-12-31 07:52
Return for Revision
2025-12-31 07:52
Revised
2026-01-01 19:30
Publication Fee Transferred
Second Decision by Editor
2026-01-16 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-16 06:04
Articles in Press
2026-01-16 06:04
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-29 07:27
Publish the Manuscript Online
2026-02-05 06:01
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Ophthalmology
Manuscript Type Observational Study
Article Title When eye disease affects the mind: Psychological burden and functioning in autoimmune ophthalmology
Manuscript Source Invited Manuscript
All Author List Matteo Capobianco, Marco Zeppieri, Simonetta Gaia Nicolosi, Giuseppe Daniele Faro, Daniele Salanitro, Marieme Khouyyi, Fabiana D’Esposito and Caterina Gagliano
ORCID
Author(s) ORCID Number
Marco Zeppieri http://orcid.org/0000-0003-0999-5545
Fabiana D’Esposito http://orcid.org/0000-0002-7938-876X
Caterina Gagliano http://orcid.org/0000-0001-8424-0068
Funding Agency and Grant Number
Corresponding Author Marco Zeppieri, Department of Ophthalmology, University Hospital of Udine, p. le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it
Key Words Rare ophthalmic disease; Autoimmune disease; Psycho-ophthalmology; Anxiety; Depressive symptoms; Quality of life; Consultation-liaison psychiatry
Core Tip Patients living with rare and autoimmune eye diseases frequently face chronic pain, fear of blindness, diagnostic uncertainty, and disruption of social and work roles. In this pilot psycho-ophthalmology case series from an integrated ophthalmology-psychology clinic, about half of the patients showed clinically relevant anxiety, and many reported markedly impaired physical and, to a lesser extent, mental quality of life, despite the small sample size. Systematic use of brief standardized instruments (hospital anxiety and depression scale and 12-item short form health survey), combined with a focused clinical interview, proved feasible in routine care and directly informed decisions about psychological or psychiatric referral. Embedding mental health assessment within ophthalmology services may help clinicians identify vulnerable patients earlier, address emotional distress and maladaptive coping, and ultimately support better adaptation to chronic visual disease and complex immunomodulatory treatments.
Publish Date 2026-02-05 06:01
Citation

Capobianco M, Zeppieri M, Nicolosi SG, Faro GD, Salanitro D, Khouyyi M, D’Esposito F, Gagliano C. When eye disease affects the mind: Psychological burden and functioning in autoimmune ophthalmology. World J Clin Cases 2026; 14(4): 117692

URL https://www.wjgnet.com/2307-8960/full/v14/i4/117692.htm
DOI https://dx.doi.org/10.12998/wjcc.v14.i4.117692
Full Article (PDF) WJCC-14-117692-with-cover.pdf
STROBE Statement 117692-STROBE-statement.pdf
Manuscript File 117692_Auto_Edited_015849.docx
Answering Reviewers 117692-answering-reviewers.pdf
Audio Core Tip 117692-audio.m4a
Biostatistics Review Certificate 117692-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 117692-conflict-of-interest-statement.pdf
Copyright License Agreement 117692-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 117692-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 117692-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 117692-non-native-speakers.pdf
Peer-review Report 117692-peer-reviews.pdf
Scientific Misconduct Check 117692-scientific-misconduct-check.png
Scientific Editor Work List 117692-scientific-editor-work-list.pdf
CrossCheck Report 117692-crosscheck-report.pdf