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Articles Published Processes
6/9/2026 9:23:52 AM | Browse: 0 | Download: 0
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Received |
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2025-12-24 05:42 |
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Peer-Review Started |
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2025-12-24 05:43 |
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First Decision by Editorial Office Director |
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2026-01-07 10:25 |
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Return for Revision |
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2026-01-07 13:50 |
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Revised |
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2026-01-21 13:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-25 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-25 04:41 |
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Articles in Press |
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2026-02-25 04:41 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-26 08:25 |
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Publish the Manuscript Online |
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2026-06-09 09:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Nanoscience & Nanotechnology |
| Manuscript Type |
Basic Study |
| Article Title |
Low-pH preconditioned macrophage-derived extracellular vesicles enable targeted and enhanced paclitaxel therapy in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Hui Wang, Ming-Li Hu, Min Shi, Jia-Li Ma, Jing Yang and Yu-Gang Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of the Science and Technology Commission of Shanghai Municipality |
23ZR1458300 |
| Key Discipline Project of Shanghai Municipal Health System |
2024ZDXK0004 |
| Special project for Clinical Research in Health Industry of Shanghai Municipal Health Commission |
20254Y0097 |
| Youth Project Fund of Changning District Health Commission |
2024QN02 |
| Research Fund of Key Laboratory for Translational Research and Innovative Therapeutics of Gastrointestinal Oncology |
ZDSYS-2023-04 |
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| Corresponding Author |
Yu-Gang Wang, Professor, Department of Gastroenterology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. wyg0061@shtrhospital.com |
| Key Words |
Extracellular vesicles; Low-pH preconditioning; Targeted delivery; Combined therapy; Gastric cancer |
| Core Tip |
In this study, we report a microenvironment-inspired strategy to customize macrophage-derived extracellular vesicles (EVs) through low-pH preconditioning, mimicking the acidic characteristics of the tumor microenvironment. This approach markedly enhances EVs' tumor targeting and endows them with a distinct miRNA cargo associated with reported anti-tumor functions. When used as nanocarriers for paclitaxel (PTX), the resulting biomimetic system (PTX@LP-EV) achieves superior anti-tumor efficacy in gastric cancer models. Mechanistically, EV-borne miRNAs induced by tumor microenvironmental stimulation may cooperatively suppress pro-tumorigenic genes, which is consistent with the observed enhanced therapeutic effects. |
| Publish Date |
2026-06-09 09:23 |
| Citation |
Wang JH, Hu ML, Shi M, Ma JL, Yang J, Wang YG. Low-pH preconditioned macrophage-derived extracellular vesicles enable targeted and enhanced paclitaxel therapy in gastric cancer. World J Gastrointest Oncol 2026; 18(6): 117697
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i6/117697.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i6.117697 |
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