ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Permissions |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Prospective Study |
Article Title |
Impact of discontinuing non-steroidal antiinflammatory drugs on long-term recurrence in colonic diverticular bleeding
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Naoyoshi Nagata, Ryota Niikura, Tomonori Aoki, Takuro Shimbo, Katsunori Sekine, Hidetaka Okubo, Kazuhiro Watanabe, Toshiyuki Sakurai, Chizu Yokoi, Junichi Akiyama, Mikio Yanase, Masashi Mizokami and Naomi Uemura |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Research from the National Center for Global Health and Medicine |
26A-201 |
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Corresponding Author |
Naoyoshi Nagata, MD, Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo 162-8655, Japan. nnagata_ncgm@yahoo.co.jp |
Key Words |
Non-steroidal anti-inflammatories; Drug withdrawal; Diverticular hemorrhage; Hemodialysis; Antithrombotic drugs |
Core Tip |
The probability of recurrence of diverticular bleeding at 1, 12, and 24 mo was 3.1%, 27%, and 38%, respectively. Of the 41 non-steroidal anti-inflammatory drugs (NSAIDs) users on admission, 26 (63%) discontinued NSAID use at discharge. The probability of recurrence at 12 mo was 9.4% in discontinuing NSAID users compared with 77% in continuing users (P < 0.01, log-rank test). The hazard ratio for recurrence in the discontinuing NSAIDs users was 0.06 after adjusting for age > 70 years, right-sided diverticula, history of hypertension, and hemodialysis. No patients developed cerebrocardiovascular events during follow-up. This study provides new information on risk reduction strategies for diverticular bleeding. |
Publish Date |
2015-01-27 15:33 |
Citation |
Nagata N, Niikura R, Aoki T, Shimbo T, Sekine K, Okubo H, Watanabe K, Sakurai T, Yokoi C, Akiyama J, Yanase M, Mizokami M, Uemura N. Impact of discontinuing non-steroidal antiinflammatory drugs on long-term recurrence in colonic diverticular bleeding. World J Gastroenterol 2015; 21(4): 1292-1298 |
URL |
http://www.wjgnet.com/1007-9327/full/v21/i4/1292.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v21.i4.1292 |