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Articles Published Processes
10/12/2026 6:27:06 AM | Browse: 1 | Download: 0
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Received |
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2025-12-16 02:36 |
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Peer-Review Started |
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2025-12-16 09:54 |
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First Decision by Editorial Office Director |
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2025-12-31 07:55 |
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Return for Revision |
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2025-12-31 07:55 |
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Revised |
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2026-01-19 10:17 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-03 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-03 06:48 |
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Articles in Press |
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2026-02-03 06:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-17 02:11 |
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Publish the Manuscript Online |
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2026-10-12 06:27 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Editorial |
| Article Title |
Revisiting the pancreas-liver axis in diabetes: The emerging role of exosomal miR-375-3p
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Bich Ngoc Hoang Thi, Thang Viet Luong, Hai Nguyen Ngoc Dang, Hau Phuc Tran and Trung Tran Nguyen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Trung Tran Nguyen, Lecturer, PhD, Researcher, Nguyen Tat Thanh Hi-Tech Institute, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, Ho Chi Minh City 700000, Viet Nam. nguyen.trung@ntt.edu.vn |
| Key Words |
Type 2 diabetes mellitus; Beta-cell glucotoxicity; Exosomal miRNA; Hepatic insulin resistance; Pancreatic-liver communication |
| Core Tip |
Type 2 diabetes mellitus is characterized by progressive β-cell dysfunction and hepatic insulin resistance, yet the molecular signals linking pancreatic stress to impaired liver glucose metabolism remain incompletely defined. Recent evidence has revealed that exosomal miR-375-3p is a novel mediator of pancreas-liver communication, whereby glucotoxic β cells transfer regulatory miRNA cargo to hepatocytes to repress protein for immunoglobulin kappa J region, disrupt protein kinase B/glycogen synthase kinase signaling, and reduce hepatic glycogen storage. This editorial highlights the conceptual importance of this exosome-miRNAs axis, critically evaluates its current limitations, and discusses its potential implications for understanding disease progression, biomarker development, and therapeutic targeting in type 2 diabetes. |
| Publish Date |
2026-10-12 06:27 |
| Citation |
Hoang Thi BN, Luong TV, Dang HNN, Tran HP, Nguyen TT. Revisiting the pancreas-liver axis in diabetes: The emerging role of exosomal miR-375-3p. World J Diabetes 2026; 17(10): 117752
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i10/117752.htm |
| DOI |
https://doi.org/10.4239/wjd.117752 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
