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Publication Name World Journal of Cardiology
Manuscript ID 117807
Country Spain
Received
2025-12-16 00:34
Peer-Review Started
2025-12-16 00:35
First Decision by Editorial Office Director
2026-01-06 09:41
Return for Revision
2026-01-06 09:41
Revised
2026-01-12 00:20
Publication Fee Transferred
Second Decision by Editor
2026-03-05 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-05 11:46
Articles in Press
2026-03-05 11:46
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-10 06:13
Publish the Manuscript Online
2026-06-18 09:51
ISSN 1949-8462 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Correspondence
Article Title Letter to the Editor: Beta-blockers vs calcium channel blockers in heart failure with preserved ejection fraction: An old question in need of new answers
Manuscript Source Invited Manuscript
All Author List Rafael Vidal-Perez and Jose Manuel Vazquez-Rodriguez
ORCID
Author(s) ORCID Number
Rafael Vidal-Perez http://orcid.org/0000-0001-9944-8363
Jose Manuel Vazquez-Rodriguez http://orcid.org/0000-0003-0888-6937
Funding Agency and Grant Number
Corresponding Author Rafael Vidal-Perez, Servicio de Cardiología, Unidad de Imagen y Función Cardíaca, Complexo Hospitalario Universitario A Coruña Centro de Investigación Biomédica en Red-Instituto de Salud Carlos III, As Xubias de Arriba-84, A Coruña 15006, Galicia, Spain. rafavidal@hotmail.com
Key Words Heart failure with preserved ejection fraction; Beta-blockers; Calcium channel blockers; Phenotype-guided therapy; Heart rate control
Core Tip Heart failure with preserved ejection fraction (HFpEF) remains a heterogeneous syndrome lacking robust disease-modifying therapies. This editorial critically examines the long-standing debate between beta-blockers and calcium channel blockers in HFpEF, integrating evidence from meta-analyses, observational studies, and a recent retrospective comparison. While beta-blockers may confer modest benefits in selected phenotypes - particularly in patients with atrial fibrillation or coronary artery disease - their potential to worsen chronotropic incompetence limits universal applicability. Calcium channel blockers appear largely safe and may reduce hospitalizations in specific settings. Overall, the analysis underscores the need for phenotype-driven, individualized treatment strategies and prospective trials to guide therapy in HFpEF.
Publish Date 2026-06-18 09:51
Citation

Vidal-Perez R, Vazquez-Rodriguez JM. Letter to the Editor: Beta-blockers vs calcium channel blockers in heart failure with preserved ejection fraction: An old question in need of new answers. World J Cardiol 2026; 18(6): 117807

URL https://www.wjgnet.com/1949-8462/full/v18/i6/117807.htm
DOI https://doi.org/10.4330/wjc.117807
Full Article (PDF) WJC-18-117807-with-cover.pdf
Manuscript File 117807_Auto_Edited_063927.docx
Answering Reviewers 117807-answering-reviewers.pdf
Audio Core Tip 117807-audio.mp3
Conflict-of-Interest Disclosure Form 117807-conflict-of-interest-statement.pdf
Copyright License Agreement 117807-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 117807-non-native-speakers.pdf
Peer-review Report 117807-peer-reviews.pdf
Scientific Misconduct Check 117807-scientific-misconduct-check.png
Scientific Editor Work List 117807-scientific-editor-work-list.pdf
CrossCheck Report 117807-crosscheck-report.pdf