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Articles Published Processes
4/8/2026 7:28:55 AM | Browse: 0 | Download: 0
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Received |
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2025-12-16 09:04 |
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Peer-Review Started |
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2025-12-16 09:04 |
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First Decision by Editorial Office Director |
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2026-01-16 03:33 |
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Return for Revision |
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2026-01-16 03:33 |
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Revised |
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2026-01-27 01:22 |
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Publication Fee Transferred |
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2026-01-31 12:49 |
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Second Decision by Editor |
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2026-02-26 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-26 04:57 |
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Articles in Press |
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2026-02-26 04:57 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-27 11:37 |
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Publish the Manuscript Online |
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2026-04-08 07:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Fang Zhang, Guan-Hua Lv, Shu-Jian An, Xi-Ran Yang, Wen-Zhao Guo, Chen-Yang Yu and Cheng-Hui Zhu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Joint Program of the Science and Technology Plan of Liaoning Province (Natural Science Foundation – General Program) |
No. 2024012225-JH4/4800 |
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| Corresponding Author |
Cheng-Hui Zhu, Associate Chief Physician, MD, Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Provincial Institute of Traditional Chinese Medicine, No. 60 Huanghebei Street, Huanggu District, Shenyang 110031, Liaoning Province, China. zhuchenghui2005@163.com |
| Key Words |
Hypoxia-inducible factor 1-alpha; BCL2/adenovirus E1B 19 kDa interacting protein 3; Precancerous lesions of gastric cancer; Mitophagy; Glycolysis |
| Core Tip |
In the hypoxic microenvironment of gastric precancerogenesis, the transcription factor hypoxia-inducible factor 1-alpha (HIF-1α) is a master regulator of both mitophagy and glycolysis. Our study reveals that sustained overexpression of HIF-1α during the progression of precancerous gastric lesions drives autophagic failure via the BCL2/adenovirus E1B 19 kDa interacting protein 3 pathway. This defective autophagy is tightly linked to a subsequent metabolic switch, characterized by the late-stage activation of glycolysis. This work identifies the dysregulation of the HIF-1α/BCL2/adenovirus E1B 19 kDa interacting protein 3 axis as a key event linking failed mitochondrial quality control to the pro-tumorigenic glycolytic reprogramming in the stomach. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
Zhang XF, Lv GH, An SJ, Yang XR, Guo WZ, Yu CY, Zhu CH. Dysregulation of the HIF-1α/BNIP3 axis links defective mitophagy to glycolytic reprogramming in a rat model of gastric precancerogenesis. World J Gastrointest Oncol 2026; 18(4): 117815 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/117815.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.117815 |
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