BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/30/2026 1:50:36 AM | Browse: 2 | Download: 1
 |
Received |
|
2025-12-23 10:07 |
|
Peer-Review Started |
|
2025-12-23 10:07 |
|
First Decision by Editorial Office Director |
|
2026-01-20 09:43 |
|
Return for Revision |
|
2026-01-20 09:43 |
|
Revised |
|
2026-01-29 02:05 |
|
Publication Fee Transferred |
|
2026-02-13 08:29 |
|
Second Decision by Editor |
|
2026-04-08 02:38 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-04-08 08:43 |
|
Articles in Press |
|
2026-04-08 08:43 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-07-17 00:47 |
|
Publish the Manuscript Online |
|
2026-09-30 01:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chen-Xi Wang, Li-Ming Wang, Zhi-Fei Fu, Xin Zhao, Li-Feng Han and Yue-Fen Lou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Hongkou District Health and Wellness Committee Medical Research Project |
Hongwei 2403-07 |
| Shanghai Hongkou District Health and Wellness Committee Traditional Chinese Medicine Research Project |
HKZYY-2025-35 |
| Shanghai Fourth People’s Hospital Research Launch Special Project |
sykyqd09701 |
| Shanghai Fourth People’s Hospital Discipline Promotion Project |
SY-XKZT-2024-1013 |
| Shanghai 2023 “Science and Technology Innovation Action Plan” Biomedical Technology Support Special Project |
23S21900900 |
| National Natural Science Foundation of China |
82274362 |
|
| Corresponding Author |
Yue-Fen Lou, Chief Pharmacist, Department of Pharmacy, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, No. 1279 Sanmen Road, Hongkou District, Shanghai 200434, China. louyuefen@tongji.edu.cn |
| Key Words |
Emodin; Cholestatic liver injury; Metabolomics; Bile acid metabolism; Gut microbiota |
| Core Tip |
Our study revealed the beneficial effects of emodin (Emo) in alleviating cholestatic liver injury (CLI). Bile acid metabolism was altered during CLI, which was normalized by Emo. Emo altered gut microbiota composition. Fecal microbiota transplantation confirmed the microbiota-dependent anti-CLI efficacy of Emo and its therapeutic effect on the gut microbiota, especially Escherichia-Shigella. These findings will provide new insights into exploring the anti-CLI mechanism of Emo and its potential treatment strategies for CLI. |
| Publish Date |
2026-09-30 01:50 |
| Citation |
Wang CX, Wang LM, Fu ZF, Zhao X, Han LF, Lou YF. Emodin ameliorates cholestatic liver injury by regulating bile acid metabolism and gut microbiota in mice. World J Gastroenterol 2026; 32(44): 117819
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i44/117819.htm |
| DOI |
https://doi.org/10.3748/wjg.117819 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
