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Articles Published Processes
3/23/2026 8:54:22 AM | Browse: 1 | Download: 1
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Received |
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2025-12-17 02:36 |
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Peer-Review Started |
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2025-12-17 02:36 |
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First Decision by Editorial Office Director |
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2025-12-31 07:57 |
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Return for Revision |
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2025-12-31 07:57 |
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Revised |
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2026-01-04 03:46 |
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Publication Fee Transferred |
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2026-01-06 05:25 |
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Second Decision by Editor |
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2026-02-09 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-09 05:38 |
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Articles in Press |
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2026-02-09 05:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-12 07:41 |
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Publish the Manuscript Online |
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2026-03-23 08:54 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Landiolol modulates sodium 1.5 ion and connexin-43 to reduce sepsis ventricular arrhythmias
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Fei Hu, Ling-Yu Bai, Ming Zhao, Kui-Ying Ma, Li-Ying Xuan and Xin Qi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Inner Mongolia Natural Science Foundation Project of China |
No. 2020MS08031 |
| Inner Mongolia Natural Science Foundation Project of China |
No. 2021MS08069 |
| Inner Mongolia Natural Science Foundation Project of China |
No. 2023LHMS08082 |
| Education Institutions in Inner Mongolia Autonomous Region of China |
No. NJZY22456 |
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| Corresponding Author |
Xin Qi, Chief Physician, Department of Cardiology, Tianjin Union Medicine Center, The First Affiliated Hospital of Nankai University, No. 190 Jieyuan Road, Hongqiao District, Tianjin 300121, China. qixinx2011@126.com |
| Key Words |
Sodium 1.5 ion channel; Connexin-43; Ventricular arrhythmia; Sepsis; Landiolol |
| Core Tip |
Landiolol, a beta-blocker, can treat ventricular arrhythmias caused by sepsis. In this study, a rat sepsis model was first established, and the animals then received landiolol. Cardiac electrophysiological experiments and ultrastructural observations of the myocardium were conducted to clarify the electrophysiological effects and mechanisms of landiolol on ventricular myocytes in septic rats. It showed that landiolol could reduce the occurrence of ventricular arrhythmias in sepsis rats through inhibiting inflammatory cells, reducing myocardial fibrosis, reversing ventricular remodeling, and decreasing the expression of connexin-43 and sodium 1.5 ion. |
| Publish Date |
2026-03-23 08:54 |
| Citation |
Hu PF, Bai LY, Zhao M, Ma KY, Xuan LY, Qi X. Landiolol modulates sodium 1.5 ion and connexin-43 to reduce sepsis ventricular arrhythmias. World J Cardiol 2026; 18(3): 117821 |
| URL |
https://www.wjgnet.com/1949-8462/full/v18/i3/117821.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i3.117821 |
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