| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Distinct early gut microbiota patterns by delivery mode within 100 hours of birth
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Palittiya Sintusek, Pavit Klomkliew, Suthida Visedthorn, Kittima Phutthawong, Tanawan Noicharoen, Areewan Soontornsook, Duc Long Tran and Sunchai Payungporn |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ratchadapiseksompotch Funds, Graduate Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand |
RA67/040 |
| Thailand Science research and Innovation Fund Chulalongkorn University |
HEA_FF_69_225_3000_031 |
|
| Corresponding Author |
Palittiya Sintusek, Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology, Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Chulalongkorn University, 1873 Rama IV, Pathumwan, Bangkok 10330, Thailand. palittiya.s@chula.ac.th |
| Key Words |
Gut microbiota; Neonate; Early life; Feeding; Normal labor; Cesarean section |
| Core Tip |
This study characterizes the gut microbiota of healthy neonates within the first 100 hours after birth, which is a critical yet understudied window of microbial establishment. Neonates delivered by vaginal delivery showed early enrichment of Bifidobacterium, whereas those delivered by cesarean delivery exhibited a higher abundance of skin and environment-associated taxa and reduced colonization by Bifidobacterium despite predominant breastfeeding. These findings highlight the role of delivery mode as a key determinant of early microbial assembly and the need for targeted microbiota-supportive strategies for cesarean-born neonates. |
| Publish Date |
2026-05-13 08:18 |
| Citation |
Sintusek P, Klomkliew P, Visedthorn S, Phutthawong K, Noicharoen T, Soontornsook A, Tran DL, Payungporn S. Distinct early gut microbiota patterns by delivery mode within 100 hours of birth. World J Clin Pediatr 2026; 15(2): 117841 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i2/117841.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i2.117841 |
