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Articles Published Processes
6/12/2026 10:39:46 AM | Browse: 0 | Download: 0
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Received |
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2025-12-18 02:54 |
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Peer-Review Started |
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2025-12-18 02:54 |
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First Decision by Editorial Office Director |
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2026-01-12 09:51 |
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Return for Revision |
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2026-01-12 09:51 |
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Revised |
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2026-01-16 07:27 |
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Publication Fee Transferred |
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2026-01-19 02:42 |
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Second Decision by Editor |
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2026-03-04 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-04 04:05 |
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Articles in Press |
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2026-03-04 04:05 |
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Edit the Manuscript by Language Editor |
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2026-03-09 04:07 |
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Typeset the Manuscript |
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2026-06-03 00:46 |
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Publish the Manuscript Online |
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2026-06-12 10:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Differential metabolites facilitate metabolic dysfunction-associated fatty liver disease malignancy via immune evasion and M2-polarized macrophages
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Yang, Wen-Li Sai, Xiao-Xiao Xia, Hao Tang, Min Xu, Qun Xie, Deng-Fu Yao and Min Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
32470985, 81673241 |
| Nantong Science and Technology Project |
MS2024051 |
| Nantong Federation for the Prevention and Control of Infectious Diseases |
NTCRB2025016 |
| Nantong Health Commission of China |
QN2025064 |
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| Corresponding Author |
Deng-Fu Yao, PhD, Postdoc, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com |
| Key Words |
Differential metabolites; Carnitine palmitoyl transferase-II; Immune escape; Differentially expressed genes; M2-polarized macrophages; Hepatocarcinogenesis |
| Core Tip |
Dynamic alterations of differential metabolites and immune cells were very useful for understanding metabolic dysfunction-associated fatty liver disease malignancy, with loss carnitine palmitoyl transferase-II activity and significant phosphatidylcholines and sphingomyelins via steroid biosynthesis. Interestingly, immune cells in a fat-rich microenvironment characterized by a decrease in T-cell dysfunction, an increase in programmed death ligand 1 expression for immune escape and M2-polarized macrophages to promote metabolic dysfunction-associated fatty liver disease malignancy. |
| Publish Date |
2026-06-12 10:39 |
| Citation |
Yang J, Sai WL, Xia XX, Tang H, Xu M, Xie Q, Yao DF, Yao M. Differential metabolites facilitate metabolic dysfunction-associated fatty liver disease malignancy via immune evasion and M2-polarized macrophages. World J Gastroenterol 2026; 32(24): 117849
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i24/117849.htm |
| DOI |
https://doi.org/10.3748/wjg.117849 |
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