Publication Name	World Journal of Gastroenterology
Manuscript ID	11786
Country	Japan

Received	2014-06-04 18:38
Peer-Review Started	2014-06-04 20:21
First Decision by Editorial Office Director
Return for Revision	2014-06-20 20:34
Revised	2014-07-04 10:19
Publication Fee Transferred
Second Decision by Editor	2014-07-30 10:08
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-07-30 10:25
Articles in Press	2014-07-30 10:50
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-18 16:56
Publish the Manuscript Online	2015-01-06 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection
Manuscript Source	Unsolicited Manuscript
All Author List	Xu Liu, Ayako Hakucho, Jinyao Liu and Tatsuya Fujimiya
Funding Agency and Grant Number	Funding Agency Grant Number Japan Society for the Promotion of Science’s Grants-in-Aid for Scientific Research 22590635
Corresponding Author	Jinyao Liu, MD, PhD, Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. czhliu@yamaguchi-u.ac.jp
Key Words	Ethanol; Hepatic class-1 alcohol dehydrogenase; Ethanol elimination; Hepatic steatosis; Liver function; Liver resection
Core Tip	Pair-feeding was performed with control or ethanol liquid diet for 28 d in sham-operated (Sham) and partial hepatectomy (PH) rats. In PH rats, ethanol induced hepatic steatosis with liver dysfunction and higher residual blood ethanol concentrations without up-regulation of hepatic class-1 alcohol dehydrogenase (Adh1) gene expression, which was present in the Sham-ethanol rats. One week after PH, liver weight, function, and lipid metabolism-related gene expressions recovered; but Adh1 gene expression did not. Desensitization to post-hepatectomy ethanol treatment and the slow recovery of Adh1 expression from PH enhanced the susceptibility to ethanol-induced hepatic steatosis in the rats post PH.
Publish Date	2015-01-06 09:08
Citation	Liu X, Hakucho A, Liu J, Fujimiya T. Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection. World J Gastroenterol 2014; 20(48): 18249-18259
URL	http://www.wjgnet.com/1007-9327/full/v20/i48/18249.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i48.18249

Full Article (PDF)	WJG-20-18249.pdf
Full Article (Word)	WJG-20-18249.doc
Manuscript File	11786-Review.doc
Answering Reviewers	11786-Answering Reviewers.pdf
Copyright License Agreement	11786-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11786-Languge certificate.pdf
Peer-review Report	11786-Peer review.pdf
Scientific Misconduct Check	11786-CorssCheck.jpg
Scientific Editor Work List	11786-Scientific editor work list.pdf