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Articles Published Processes
8/7/2026 9:40:20 AM | Browse: 1 | Download: 0
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Received |
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2025-12-18 02:10 |
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Peer-Review Started |
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2025-12-18 02:10 |
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First Decision by Editorial Office Director |
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2026-02-26 07:34 |
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Return for Revision |
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2026-02-27 02:31 |
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Revised |
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2026-04-12 17:17 |
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Publication Fee Transferred |
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2026-04-15 13:17 |
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Second Decision by Editor |
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2026-05-25 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-25 07:19 |
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Articles in Press |
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2026-05-25 07:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-28 01:55 |
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Publish the Manuscript Online |
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2026-08-07 09:40 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
ASAP3 disrupts ASAP1-ARHGAP12 to inhibit RhoA and yes-associated protein/transcriptional coactivator with PDZ-binding motif, suppressing gastric cancer progression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xian-Bin Huang, Yuan Deng, Shi-Yi Gong, Miao Yu and Hui Cai |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hui Cai, MD, Professor, The First Clinical Medical College of Lanzhou University, No. 1 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. caialonteam@163.com |
| Key Words |
Gastric cancer; ASAP3; RhoA activity; ASAP1-ARHGAP12; Yes-associated protein/transcriptional coactivator with PDZ-binding motif |
| Core Tip |
Our study identified ASAP3 as a novel tumor suppressor in gastric cancer (GC) that may suppress RhoA activity by disrupting the ASAP1-ARHGAP12 interaction, thereby activating the Hippo pathway and suppressing yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ)-mediated oncogenesis. These findings clarify the context-dependent function of ASAP3, uncover a new regulatory mechanism of the RhoA/YAP/TAZ axis, and provide a potential prognostic biomarker and therapeutic target for GC. Future studies will focus on validating ASAP3’s prognostic value in clinical cohorts and developing small-molecule modulators of the ASAP3 interfered ASAP1-ARHGAP12 interaction for GC therapy. |
| Publish Date |
2026-08-07 09:40 |
| Citation |
Huang XB, Deng Y, Gong SY, Yu M, Cai H. ASAP3 disrupts ASAP1-ARHGAP12 to inhibit RhoA and yes-associated protein/transcriptional coactivator with PDZ-binding motif, suppressing gastric cancer progression. World J Gastrointest Oncol 2026; 18(8): 117876
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i8/117876.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i8.117876 |
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