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Articles Published Processes
7/13/2026 9:40:37 AM | Browse: 2 | Download: 0
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Received |
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2025-12-18 10:59 |
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Peer-Review Started |
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2025-12-18 11:00 |
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First Decision by Editorial Office Director |
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2026-01-14 02:53 |
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Return for Revision |
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2026-01-14 02:53 |
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Revised |
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2026-02-04 01:51 |
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Publication Fee Transferred |
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2026-02-11 01:05 |
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Second Decision by Editor |
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2026-04-03 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-03 06:12 |
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Articles in Press |
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2026-04-03 06:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-25 08:08 |
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Publish the Manuscript Online |
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2026-07-13 09:40 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Case Report |
| Article Title |
Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue Wen, Jie-Ying Qiu, Jun Li, Zheng-Rong Mao and Wei-Qiang Wu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wei-Qiang Wu, Professor, Department of Pathology, First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. wuweiqiang@zju.edu.cn |
| Key Words |
Duodenal tumor; Pyloric gland-type adenoma; Signet-ring cell carcinoma; Immunohistochemistry; Next-generation sequencing; Case report |
| Core Tip |
We report the first documented case of duodenal signet-ring cell carcinoma arising from a pyloric gland adenoma, characterized by distinctive molecular findings identified through next-generation sequencing. Our data highlight variants in RN7SL1 and MUC6, as well as altered expression of the somatic mitochondrial genes MT-CO2, MT-CO1, MT-ND1, MT-ND4 and MT-CO3, suggesting a novel pathogenic mechanism. This case underscores the value of next-generation sequencing in diagnosing rare gastrointestinal neoplasms and broadens our understanding of signet-ring cell carcinoma development. |
| Publish Date |
2026-07-13 09:40 |
| Citation |
Wen X, Qiu JY, Li J, Mao ZR, Wu WQ. Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report. World J Gastrointest Oncol 2026; 18(7): 117886
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i7/117886.htm |
| DOI |
https://doi.org/10.4251/wjgo.117886 |
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