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Articles Published Processes
5/14/2026 9:17:11 AM | Browse: 6 | Download: 40
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Received |
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2025-12-22 08:07 |
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Peer-Review Started |
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2025-12-22 08:07 |
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First Decision by Editorial Office Director |
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2026-01-06 07:09 |
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Return for Revision |
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2026-01-06 07:09 |
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Revised |
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2026-01-16 09:46 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-02 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-02 09:55 |
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Articles in Press |
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2026-03-02 09:55 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-27 01:53 |
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Publish the Manuscript Online |
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2026-05-14 09:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Editorial |
| Article Title |
From bile acids to yes-associated protein: A bidirectional switch for cholangiocarcinoma therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shu-Yuan Zhang, Hui Yu, Yin Mi and Fan-Kai Xiao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Youth Foundation of Henan Scientific Committee |
No. 202300410416 |
| Henan Province Medical Science, Technology Breakthrough Plan Project |
No. LHGJ20190033 |
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| Corresponding Author |
Fan-Kai Xiao, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou 450052, Henan Province, China. xfkw@hotmail.com |
| Key Words |
Bile acids; Yes-associated protein; Cholangiocarcinoma; Gut microbiota; Therapeutic targets |
| Core Tip |
Bile acids (BAs) exert complex, structure-dependent regulatory effects on the Hippo-yes-associated protein pathway in gastrointestinal malignancies. These editorial highlights a pivotal “bidirectional switch” mechanism where glycochenodeoxycholic acid and deoxycholic acid induce opposing outcomes in cholangiocarcinoma. By integrating the physicochemical distinctions between conjugated and unconjugated BAs with their dynamic interplay in gut microbiota dysbiosis, we propose a multidimensional “microbiota-BA-Hippo” regulatory network. Targeting this axis offers novel precision therapeutic strategies for managing cholangiocarcinoma and metabolic disorders. |
| Publish Date |
2026-05-14 09:17 |
| Citation |
Zhang SY, Yu H, Mi Y, Xiao FK. From bile acids to yes-associated protein: A bidirectional switch for cholangiocarcinoma therapy. World J Gastrointest Oncol 2026; 18(5): 117990 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i5/117990.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i5.117990 |
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