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Articles Published Processes
8/5/2026 5:45:45 AM | Browse: 1 | Download: 1
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Received |
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2026-01-05 08:47 |
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Peer-Review Started |
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2026-01-05 08:48 |
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First Decision by Editorial Office Director |
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2026-02-10 10:37 |
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Return for Revision |
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2026-02-10 10:37 |
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Revised |
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2026-02-10 20:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-18 02:51 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-18 07:19 |
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Articles in Press |
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2026-05-18 07:19 |
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Edit the Manuscript by Language Editor |
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2026-05-20 17:05 |
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Typeset the Manuscript |
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2026-07-29 08:33 |
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Publish the Manuscript Online |
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2026-08-05 05:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Opinion Review |
| Article Title |
Non-exonuclease domain POLE mutations and their biological significance in colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ilektra Kyrochristou, Gerasimia D Kyrochristou and Georgios D Lianos |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ilektra Kyrochristou, Department of General Surgery, University Hospital of Ioannina, Stavros Niarchos Avenue, Ioannina 45500, Greece. electra.cyro@gmail.com |
| Key Words |
Non-exonuclease; Colorectal cancer; Molecular; Microsatellite stable cancers; POLE-variants |
| Core Tip |
Non-exonuclease domain (EDM) POLE mutations are emerging as a potentially important molecular subgroup in colorectal cancer, particularly within microsatellite stable tumors traditionally considered poorly immunogenic. Increasing evidence suggests that these variants may coexist with elevated tumor mutational burden, DNA repair alterations, and recurrent co-mutational patterns involving KRAS, PIK3CA, MLH3, and MSH3. Rather than acting as isolated biomarkers, non-EDM POLE mutations appear to influence tumor biology through their broader genomic context. Their recognition highlights the limitations of relying exclusively on microsatellite instability/mismatch repair status for molecular stratification and supports the development of integrated biomarker models incorporating POLE status, tumor mutational burden, and co-mutational profiles. However, the current evidence remains preliminary, and clinical interpretation should remain cautious until prospective and functional validation studies become available. |
| Publish Date |
2026-08-05 05:45 |
| Citation |
Kyrochristou I, Kyrochristou GD, Lianos GD. Non-exonuclease domain POLE mutations and their biological significance in colorectal cancer. World J Gastroenterol 2026; 32(32): 118014
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i32/118014.htm |
| DOI |
https://doi.org/10.3748/wjg.118014 |
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