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5/29/2026 8:41:27 AM | Browse: 1 | Download: 14
Publication Name World Journal of Transplantation
Manuscript ID 118088
Country United States
Received
2025-12-23 08:40
Peer-Review Started
2025-12-23 08:40
First Decision by Editorial Office Director
2025-12-29 09:13
Return for Revision
2025-12-29 09:13
Revised
2026-01-05 20:22
Publication Fee Transferred
Second Decision by Editor
2026-02-14 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-14 09:50
Articles in Press
2026-02-14 09:50
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-03-30 14:31
Publish the Manuscript Online
2026-05-29 08:41
ISSN 2220-3230 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Retrospective Study
Article Title Rethinking procurement biopsy in donors with normal renal function: A barrier to kidney utilization without survival benefit
Manuscript Source Invited Manuscript
All Author List Lena Sibulesky, Daniel M Kaufman, Ramasamy Bakthavatsalam, Nicolae Leca and James D Perkins
ORCID
Author(s) ORCID Number
Lena Sibulesky http://orcid.org/0000-0001-5435-737X
James D Perkins http://orcid.org/0000-0002-6935-0012
Funding Agency and Grant Number
Corresponding Author Lena Sibulesky, Associate Professor, MD, Division of Transplant Surgery, Department of Surgery, University of Washington Medical Center, 1959 NE Pacific Street, Seattle, WA 98195, United States. lenasi@uw.edu
Key Words Kidney transplant; Procurement biopsy; Death-censored graft survival; Donor kidney discard; Renal function
Core Tip Using national Organ Procurement and Transplantation Network data, we show that procurement biopsy in deceased donors with preserved renal function does not improve prognostic accuracy or graft survival. Instead, biopsy is associated with substantially higher discard rates and prolonged cold ischemia, with much of its adverse impact mediated through ischemic delay and early graft dysfunction. Advanced analytic approaches, including mediation, restricted mean survival time, and decision-curve analyses, demonstrate no added clinical benefit beyond standard donor and recipient characteristics. These findings challenge routine procurement biopsy in this donor population and support re-evaluating biopsy-driven acceptance practices to improve kidney utilization.
Publish Date 2026-05-29 08:41
Citation

Sibulesky L, Kaufman DM, Bakthavatsalam R, Leca N, Perkins JD. Rethinking procurement biopsy in donors with normal renal function: A barrier to kidney utilization without survival benefit. World J Transplant 2026; 16(2): 118088

URL https://www.wjgnet.com/2220-3230/full/v16/i2/118088.htm
DOI https://dx.doi.org/10.5500/wjt.v16.i2.118088
Full Article (PDF) WJT-16-118088-with-cover.pdf
Manuscript File 118088_Auto_Edited_080612.docx
Answering Reviewers 118088-answering-reviewers.pdf
Audio Core Tip 118088-audio.mp3
Biostatistics Review Certificate 118088-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 118088-conflict-of-interest-statement.pdf
Copyright License Agreement 118088-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 118088-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 118088-institutional-review-board-statement.pdf
Supplementary Material 118088-supplementary-material.pdf
Peer-review Report 118088-peer-reviews.pdf
Scientific Misconduct Check 118088-scientific-misconduct-check.png
Scientific Editor Work List 118088-scientific-editor-work-list.pdf
CrossCheck Report 118088-crosscheck-report.pdf