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Articles Published Processes
6/9/2026 9:23:52 AM | Browse: 1 | Download: 0
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Received |
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2025-12-25 03:49 |
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Peer-Review Started |
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2025-12-25 03:49 |
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First Decision by Editorial Office Director |
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2026-01-07 10:25 |
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Return for Revision |
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2026-01-09 07:47 |
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Revised |
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2026-01-18 13:40 |
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Publication Fee Transferred |
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2026-01-19 11:55 |
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Second Decision by Editor |
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2026-02-25 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-25 03:48 |
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Articles in Press |
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2026-02-25 03:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-28 14:32 |
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Publish the Manuscript Online |
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2026-06-09 09:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Cadherin 6 drives epithelial-mesenchymal transition and oxaliplatin resistance in gastric cancer via transforming growth factor-β/Smad signaling axis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zong-Xian Zhao, Qin-Lingfei Liu, Jie-Xi Fan, Shu Zhu, Fu-Sheng Wang and Zong-Ju Hu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Anhui Provincial Health Commission |
AHWJ2023Baa20164, AHWJ2023BBa20054 |
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| Corresponding Author |
Zong-Ju Hu, Chief, PhD, Department of General Surgery, Fuyang People’s Hospital, No. 501 Sanqing Road, Yingzhou District, Fuyang 236000, Anhui Province, China. hzj130123@126.com |
| Key Words |
Cadherin-6; Gastric cancer; Epithelial-mesenchymal transition; Transforming growth factor-beta; Oxaliplatin resistance |
| Core Tip |
Gastric cancer (GC) is among the most prevalent and lethal malignancies globally and the molecular mechanisms of cadherin 6 (CDH6) in GC remain unclear. We verified that CDH6 is a key regulator in GC progression and oxaliplatin resistance. Mechanistically, CDH6 exerts its oncogenic effects by activating the transforming growth factor-β pathway and promoting epithelial-mesenchymal transition. Targeting the CDH6/transforming growth factor-β/Smad axis may serve as a promising therapeutic strategy to overcome oxaliplatin resistance and improve clinical outcomes in GC patients. |
| Publish Date |
2026-06-09 09:23 |
| Citation |
Zhao ZX, Liu QL, Fan JX, Zhu S, Wang FS, Hu ZJ. Cadherin 6 drives epithelial-mesenchymal transition and oxaliplatin resistance in gastric cancer via transforming growth factor-β/Smad signaling axis. World J Gastrointest Oncol 2026; 18(6): 118121
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i6/118121.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i6.118121 |
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