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Articles Published Processes
6/30/2026 1:35:09 PM | Browse: 0 | Download: 0
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Received |
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2025-12-25 03:37 |
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Peer-Review Started |
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2025-12-25 03:37 |
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First Decision by Editorial Office Director |
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2026-01-21 09:27 |
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Return for Revision |
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2026-01-21 09:27 |
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Revised |
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2026-02-03 10:15 |
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Publication Fee Transferred |
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2026-02-04 08:08 |
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Second Decision by Editor |
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2026-03-17 03:07 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-17 09:56 |
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Articles in Press |
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2026-03-17 09:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-24 07:33 |
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Publish the Manuscript Online |
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2026-06-30 13:35 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Curcumin nanoparticles mitigate early inflammation in severe acute pancreatitis by modulating peritoneal macrophage polarization via Nrf2/HO-1 pathway activation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lin Yang, Dong-Xu Liao, Xiao-Yu Wang, Yong-Hong Fan, Zhu-Lin Luo and Yi Wen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
32471419 |
| National Key Clinical Specialty Project |
41732113 |
| Independent Innovation Project of General Hospital of Western Theater Command |
2024-YGLC-B03 |
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| Corresponding Author |
Yi Wen, MD, Department of General Surgery & Tissue Stress Injury and Functional Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Jinniu District, Chengdu 610083, Sichuan Province, China. 13980881194@163.com |
| Key Words |
Severe acute pancreatitis; Peritoneal macrophages; Cell polarization; Curcumin; Nanoparticles |
| Core Tip |
This study provides the first evidence that curcumin nanoparticles (Cur-NPs) alleviate the early inflammatory response in severe acute pancreatitis by activating nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway to regulate polarization of peritoneal macrophages. Cur-NPs significantly ameliorated pancreatic tissue damage and reduced serum levels of inflammatory factors. Cur-NPs exerted therapeutic effects by inducing a shift in macrophage polarization from the proinflammatory M1 to anti-inflammatory M2 phenotype. Activation of the HO-1 pathway via promoted Nrf2 nuclear translocation mediated the suppressive effect of Cur-NPs on the nuclear factor kappa-B signaling pathway and oxidative stress. |
| Publish Date |
2026-06-30 13:35 |
| Citation |
Yang L, Liao DX, Wang XY, Fan YH, Luo ZL, Wen Y. Curcumin nanoparticles mitigate early inflammation in severe acute pancreatitis by modulating peritoneal macrophage polarization via Nrf2/HO-1 pathway activation. World J Gastroenterol 2026; 32(25): 118140
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i25/118140.htm |
| DOI |
https://doi.org/10.3748/wjg.118140 |
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