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Articles Published Processes
8/7/2026 9:40:26 AM | Browse: 3 | Download: 49
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Received |
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2025-12-26 01:39 |
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Peer-Review Started |
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2025-12-26 01:39 |
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First Decision by Editorial Office Director |
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2026-01-14 02:53 |
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Return for Revision |
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2026-01-14 02:53 |
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Revised |
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2026-01-28 06:43 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-04 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-04 06:24 |
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Articles in Press |
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2026-02-04 06:24 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-08 07:01 |
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Publish the Manuscript Online |
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2026-08-07 09:40 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Correspondence |
| Article Title |
Toward biology-driven transplant oncology: The role of PIVKA-II in alpha-fetoprotein-normal hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sagar Raut and Pradeep Naik E |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sagar Raut, Assistant Professor, MD, Department of Radiotherapy and Oncology, PGIMER Satellite Centre, Patiala Road, Sangrur 148001, India. snraut161@gmail.com |
| Key Words |
Des-gamma-carboxy prothrombin; Hepatocellular cancer; Alpha-fetoprotein; Hepatic transplantation; Organ transplantation; Milan criteria |
| Core Tip |
Hepatocellular carcinoma with normal alpha-fetoprotein (AFP) levels is a frequently missed when transplantation selection relies heavily on morphological criteria and AFP levels. Emerging evidence identified PIVKA-II as a robust marker of aggressive tumor biology in this subgroup. PIVKA-II successfully categorized high-risk disease despite favorable imaging and normal AFP levels. Integration of PIVKA-II with existing selection frameworks will enable a shift toward biology-driven transplant oncology and reduce post-transplant recurrence. |
| Publish Date |
2026-08-07 09:40 |
| Citation |
Raut S, Naik E P. Toward biology-driven transplant oncology: The role of PIVKA-II in alpha-fetoprotein-normal hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(8): 118170
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i8/118170.htm |
| DOI |
https://doi.org/10.4251/wjgo.118170 |
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