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5/21/2026 7:49:50 AM | Browse: 1 | Download: 1
Publication Name World Journal of Critical Care Medicine
Manuscript ID 118175
Country Qatar
Received
2025-12-28 14:23
Peer-Review Started
2025-12-28 14:25
First Decision by Editorial Office Director
2026-01-09 10:09
Return for Revision
2026-01-09 10:09
Revised
2026-01-14 14:28
Publication Fee Transferred
Second Decision by Editor
2026-02-06 02:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-06 08:13
Articles in Press
2026-02-06 08:13
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-29 02:59
Publish the Manuscript Online
2026-05-21 07:49
ISSN 2220-3141(online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Meta-Analysis
Article Title Association of early interleukin-6 level with injury severity and mortality in trauma patients: Systematic review and meta-analysis
Manuscript Source Invited Manuscript
All Author List Ibrahim Al-Hassani, Ayman El-Menyar, Mashhood Naduvilekandy, Ammar Al-Hassani and Hassan Al-Thani
ORCID
Author(s) ORCID Number
Ayman El-Menyar http://orcid.org/0000-0003-2584-953X
Ammar Al-Hassani http://orcid.org/0000-0002-2907-9248
Hassan Al-Thani http://orcid.org/0000-0001-9102-9033
Funding Agency and Grant Number
Corresponding Author Ayman El-Menyar, Department of Surgery, Hamad Medical Corporation, Al-Rayyan Street, Doha 3050, Qatar. aymanco65@yahoo.com
Key Words Serum interleukin-6; Polytrauma; Mortality; Injury severity score; Meta-analysis
Core Tip Polytrauma is associated with increased morbidity and mortality. Use and identification of biomarkers as prognostic indicators in polytraumatized patients is therefore important. Interleukin (IL)-6 is a proinflammatory cytokine that is often elevated in polytrauma patients and is linked with worse outcomes and more severe injury. However, to date, there is only one meta-analysis published in English literature 7 years ago looking at the association between injury severity and IL-6. By integrating more recent evidence, this meta-analysis provides further support for IL-6 as a prognostic indicator not only for injury severity but also for mortality among adult polytrauma patients.
Publish Date 2026-05-21 07:49
Citation

Al-Hassani I, El-Menyar A, Naduvilekandy M, Al-Hassani A, Al-Thani H. Association of early interleukin-6 level with injury severity and mortality in trauma patients: Systematic review and meta-analysis. World J Crit Care Med 2026; 15(2): 118175

URL https://www.wjgnet.com/2220-3141/full/v15/i2/118175.htm
DOI https://dx.doi.org/10.5492/wjccm.v15.i2.118175
Full Article (PDF) WJCCM-15-118175-with-cover.pdf
PRISMA 2009 Checklist 118175-PRISMA-2009-Checklist.pdf
Manuscript File 118175_Auto_Edited_072713.docx
Answering Reviewers 118175-answering-reviewers.pdf
Audio Core Tip 118175-audio.mp3
Biostatistics Review Certificate 118175-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 118175-conflict-of-interest-statement.pdf
Copyright License Agreement 118175-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 118175-non-native-speakers.pdf
Supplementary Material 118175-supplementary-material.pdf
Peer-review Report 118175-peer-reviews.pdf
Scientific Misconduct Check 118175-scientific-misconduct-check.png
Scientific Editor Work List 118175-scientific-editor-work-list.pdf
CrossCheck Report 118175-crosscheck-report.pdf