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5/29/2026 7:26:47 AM | Browse: 0 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 118191
Country Spain
Received
2025-12-28 08:55
Peer-Review Started
2025-12-28 08:55
First Decision by Editorial Office Director
2026-01-30 09:07
Return for Revision
2026-01-30 09:07
Revised
2026-02-06 12:58
Publication Fee Transferred
Second Decision by Editor
2026-03-09 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-09 08:45
Articles in Press
2026-03-09 08:45
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-05-12 03:40
Publish the Manuscript Online
2026-05-29 07:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Editorial
Article Title Beyond the score: Diet and exercise as modifiers of inflammation-based prognosis in lenvatinib-treated hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Héctor Vázquez-Lorente, Jorge Olivares-Arancibia and Julio Plaza-Diaz
ORCID
Author(s) ORCID Number
Héctor Vázquez-Lorente http://orcid.org/0000-0003-0183-6902
Jorge Olivares-Arancibia http://orcid.org/0000-0002-7186-3941
Julio Plaza-Diaz http://orcid.org/0000-0002-5171-9408
Funding Agency and Grant Number
Corresponding Author Julio Plaza-Diaz, Senior Postdoctoral Fellow, Senior Researcher, Biomedical Research Networking Center for Physiopathology of Obesity and Nutrition (CIBERObn), Alimentaciò, Nutrició Desenvolupament i Salut Mental, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Carrer de Sant Llorenç 21, Reus 43201, Spain. julioramon.plaza@urv.cat
Key Words Hepatocellular carcinoma; Lenvatinib; Inflammation-based prognostic indices; Nutritional status; Sarcopenia; Anti-inflammatory diet; Exercise/physical activity
Core Tip This article comments on Wu et al’s work, highlighting the prognostic nutritional index (PNI) as a powerful predictor of survival in patients with hepatocellular carcinoma treated with lenvatinib. Beyond its prognostic performance, the key message is that PNI reflects a dynamic and potentially modifiable state integrating nutrition, inflammation, and immune competence. Unlike static tumor characteristics, PNI may be improved through targeted lifestyle, nutritional, and supportive-care interventions. This perspective reframes inflammation-based scores from passive risk stratifiers to actionable clinical tools, supporting a more proactive and personalized approach to patient management, alongside systemic therapy.
Publish Date 2026-05-29 07:26
Citation

Vázquez-Lorente H, Olivares-Arancibia J, Plaza-Diaz J. Beyond the score: Diet and exercise as modifiers of inflammation-based prognosis in lenvatinib-treated hepatocellular carcinoma. World J Gastroenterol 2026; 32(22): 118191

URL https://www.wjgnet.com/1007-9327/full/v32/i22/118191.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i22.118191
Full Article (PDF) WJG-32-118191-with-cover.pdf
Manuscript File 118191_Auto_Edited_035827.docx
Answering Reviewers 118191-answering-reviewers.pdf
Audio Core Tip 118191-audio.mp3
Conflict-of-Interest Disclosure Form 118191-conflict-of-interest-statement.pdf
Copyright License Agreement 118191-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 118191-non-native-speakers.pdf
Peer-review Report 118191-peer-reviews.pdf
Scientific Misconduct Check 118191-scientific-misconduct-check.png
Scientific Editor Work List 118191-scientific-editor-work-list.pdf
CrossCheck Report 118191-crosscheck-report.pdf