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Articles Published Processes
8/3/2026 1:23:58 AM | Browse: 3 | Download: 20
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Received |
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2025-12-28 08:44 |
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Peer-Review Started |
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2025-12-28 08:44 |
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First Decision by Editorial Office Director |
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2026-01-20 09:15 |
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Return for Revision |
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2026-01-20 09:15 |
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Revised |
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2026-01-29 14:21 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-26 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-26 10:28 |
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Articles in Press |
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2026-02-26 10:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-23 03:24 |
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Publish the Manuscript Online |
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2026-08-03 01:23 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Causality dilemma of cytochrome P450 1A2 reduction in neonatal cholestasis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hüseyin Yiğit, Abdulkerim Gökoğlu and Sonay Gökoğlu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hüseyin Yiğit, Assistant Professor, Lecturer, PhD, Cappadocia Vocational School, Department of Medical Services and Techniques, Department of Medical Services and Techniques, Cappadocia University, Ahmet Taner Kışlalı Street, Hadosan, Nevsehir 50400, Türkiye. anatomisth@gmail.com |
| Key Words |
Cytochrome P450 1A2; Neonatal cholestasis; Biliary atresia; Detoxification; Neonatal |
| Core Tip |
This letter provides a critical perspective on the findings of Kotb et al regarding cytochrome P450 1A2 levels in neonatal cholestasis. We highlight the causality dilemma, suggesting that reduced enzyme levels may be a secondary consequence of inflammation and liver injury rather than an inherent “defect”. Furthermore, we address methodological concerns, including the lack of genetic validation and the limitations of using enzyme-linked immunosorbent assay to estimate functional metabolic capacity. We emphasize the need to explicitly differentiate between primary genetic defects and secondary downregulation induced by liver injury. We propose incorporating functional probe drug assays (e.g., caffeine clearance) and transcriptomic profiling to validate these phenotypic observations, ensuring safer pharmacological management. |
| Publish Date |
2026-08-03 01:23 |
| Citation |
Yiğit H, Gökoğlu A, Gökoğlu S. Letter to the Editor: Causality dilemma of cytochrome P450 1A2 reduction in neonatal cholestasis. World J Clin Pediatr 2026; 15(3): 118192
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| URL |
https://www.wjgnet.com/2219-2808/full/v15/i3/118192.htm |
| DOI |
https://doi.org/10.5409/wjcp.118192 |
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