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Articles Published Processes
8/18/2026 3:51:56 AM | Browse: 1 | Download: 0
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Received |
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2025-12-28 05:03 |
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Peer-Review Started |
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2025-12-28 05:03 |
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First Decision by Editorial Office Director |
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2026-01-08 09:54 |
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Return for Revision |
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2026-01-08 12:54 |
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Revised |
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2026-01-13 00:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-23 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-23 03:50 |
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Articles in Press |
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2026-01-23 03:50 |
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Edit the Manuscript by Language Editor |
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2026-01-24 04:36 |
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Typeset the Manuscript |
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2026-08-11 00:39 |
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Publish the Manuscript Online |
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2026-08-18 03:51 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Chrono-metabolic regulation of hepatic fibrosis via NR1D1-mediated hepatic stellate cell activation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hou-Shu Tu, Meng-Lin Chen, Jing Hong and Ling He |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ling He, PhD, Professor, Department of Gastroenterology, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, No. 445, Bayi Avenue, Nanchang, Jiangxi Province, China, Nanchang 330006, Jiangxi Province, China. heling118@126.com |
| Key Words |
Nuclear receptor subfamily 1 group D member 1; Chrono-metabolic axis; Liver fibrosis; Circadian rhythm; Ammonia; Hepatic stellate cell |
| Core Tip |
This review summarizes the NR1D1-centered chrono-metabolic regulation of hepatic fibrosis, detailing how circadian rhythms, HIF-1α signaling, and ammonia-mediated hepatic stellate cells activation converge. It emphasizes the therapeutic potential of chrono-informed interventions using pharmacological agents and natural compounds, offering a translational roadmap for more precise and effective antifibrotic strategies. |
| Publish Date |
2026-08-18 03:51 |
| Citation |
Tu HS, Chen ML, Hong J, He L. Chrono-metabolic regulation of hepatic fibrosis via NR1D1-mediated hepatic stellate cell activation. World J Hepatol 2026; 18(8): 118194
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i8/118194.htm |
| DOI |
https://doi.org/10.4254/wjh.118194 |
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