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Articles Published Processes
5/27/2026 8:10:53 AM | Browse: 9 | Download: 18
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Received |
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2025-12-28 08:33 |
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Peer-Review Started |
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2025-12-28 08:33 |
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First Decision by Editorial Office Director |
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2026-01-19 08:56 |
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Return for Revision |
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2026-01-19 19:35 |
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Revised |
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2026-02-01 17:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-26 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-26 10:53 |
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Articles in Press |
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2026-02-26 10:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-14 01:13 |
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Publish the Manuscript Online |
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2026-05-27 08:10 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Deciphering macrophage heterogeneity and optimizing probiotics via spatial multi-omics
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Di Meng, Bin-Bin Zhang and Jia-Nan Zhao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82204827 |
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| Corresponding Author |
Jia-Nan Zhao, Department of Cardiovascular Sciences, Temple University, 3440 North Carlisle Street, 3440 Carlisle Steet, Philadelphia, PA 19140, United States. tuv36393@temple.edu |
| Key Words |
Macrophage plasticity; Spatial transcriptomics; Spatial metabolomics; Deoxycholic acid; Precision probiotics; Colitis |
| Core Tip |
In colitis, macrophage phenotypes extend beyond the simple M1/M2 dichotomy, and their functions are shaped by the spatial microenvironment wherein they reside. Although existing spatial omics studies have delineated the cellular distributions within inflammatory regions, whether the spatial enrichment of key metabolites (such as deoxycholic acid) across distinct mucosal layers drives divergent macrophage transcriptional programs remains unclear. Spatial multiomics offers the potential to resolve the issue of metabolite-immune spatial specificity, thereby providing a reference for developing precise probiotic therapies with well-defined targets of action. |
| Publish Date |
2026-05-27 08:10 |
| Citation |
Meng D, Zhang BB, Zhao JN. Letter to the Editor: Deciphering macrophage heterogeneity and optimizing probiotics via spatial multi-omics. World J Gastrointest Pharmacol Ther 2026; 17(2): 118195
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| URL |
https://www.wjgnet.com/2150-5349/full/v17/i2/118195.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v17.i2.118195 |
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