| ISSN |
2222-0682 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Pancreatic nerves across species: Anatomical and functional disparities and their metabolic ramifications
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Si-Yu Zhuang, Lu-Jin Xu, Hai-Xia Yang, Qi-Wei Yang, Geng Chen, Bin Xu, Zhi Yu, Yun Liu and Tian-Cheng Xu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China, |
82305376 |
| Youth Talent Support Project of the China Acupuncture and Moxibustion Association |
2024-2026ZGZJXH-QNRC005 |
| The 2024 Jiangsu Province Youth Science and Technology Talent Support Project |
JSTJ-2024-380 |
| Talent Cultivation Program for Young Researchers, Key Laboratory of the Ministry of Education Project |
zyqt202501 and zyqt202503 |
|
| Corresponding Author |
Tian-Cheng Xu, Academic Fellow, CEO, Chairman, Consultant, Full Professor, Head, MD, PhD, President, Professor, Visiting Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Pancreatic nerves; Species differences; Autonomic innervation; Sympathetic nervous system; Parasympathetic nervous system; Islets of langerhans; Metabolic regulation; Diabetes; Pancreatic transplantation; Rodent models |
| Core Tip |
This review highlights the significant anatomical and functional disparities in pancreatic innervation across humans, rodents, canines, and felines. These species-specific differences profoundly impact metabolic regulation, disease susceptibility (e.g., diabetes, pancreatitis), and responses to therapeutic interventions. Understanding these variations is crucial for accurately translating findings from animal models to human clinical applications, particularly in areas like pancreatic transplantation where nerve reconstruction strategies must be species-appropriate. Recognizing the unique neuro-metabolic interactions in each species can guide the development of more effective, tailored therapies for metabolic disorders and improve the predictive value of preclinical research. |
| Publish Date |
2026-07-10 10:11 |
| Citation |
Zhuang SY, Xu LJ, Yang HX, Yang QW, Chen G, Xu B, Yu Z, Liu Y, Xu TC. Pancreatic nerves across species: Anatomical and functional disparities and their metabolic ramifications. World J Methodol 2026; 16(3): 118207
|
| URL |
https://www.wjgnet.com/2222-0682/full/v16/i3/118207.htm |
| DOI |
https://doi.org/10.5662/wjm.118207 |
