| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Editorial |
| Article Title |
Implications of Bifidobacterium and deoxycholic acid in high-fat diet-associated colitis: Harnessing macrophage plasticity to modulate disease progression
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ping-Ping Wu, Jun-Fang Liu, Salamah M Alwahsh, Xin Duan, Zhi-Wei Li, Wei Zhang and Min Xu |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Min Xu, Assistant Professor, MD, HBP Surgery and Liver Transplant Center, The First Affiliated Hospital, Zhejiang University School of Medicine, <institution>Department of General, Visceral, and Pediatric Surgery, University Medical Center Göttingen</institution>, <addr-line>Göttingen</addr-line>, <country>Germany</country>,<institution>Liver Center, Massachusetts General Hospital, Harvard Medical School</institution>, <addr-line>Boston</addr-line>, <addr-line>MA</addr-line>, <country>United States</country>, Hangzhou 310003, Zhejiang Province, China. minxu.md@gmail.com |
| Key Words |
Bifidobacterium; Deoxycholic acid; High-fat diet; Macrophage plasticity; Disease progression |
| Core Tip |
This letter comments on the manuscript recently published by Yang et al. Their study demonstrates that high-fat diets elevate fecal deoxycholic acid (DCA) levels, which subsequently drive M1 macrophage polarization and exacerbate colonic inflammation. Crucially, they show that Bifidobacterium supplementation can mitigate these pathological effects by reducing DCA concentrations and shifting macrophage polarization toward the anti-inflammatory M2 phenotype. Building upon these findings, we further reviewed the sophisticated mechanisms governing macrophage polarization and its dual role in metabolic disorders and inflammatory bowel diseases. We offer a deeper exploration of the mechanistic intricacies and contextual limitations inherent in this interaction. While expounding on the experimental merits of the article, we also identify existing knowledge gaps that warrant further investigation. Ultimately, we emphasize that harnessing the gut microbiome and its metabolites represents a critical next step in developing therapeutic strategies for intestinal inflammatory diseases. |
| Publish Date |
2026-05-20 08:22 |
| Citation |
Wu PP, Liu JF, Alwahsh SM, Duan X, Li ZW, Zhang W, Xu M. Implications of Bifidobacterium and deoxycholic acid in high-fat diet-associated colitis: Harnessing macrophage plasticity to modulate disease progression. World J Gastroenterol 2026; 32(20): 118248 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i20/118248.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i20.118248 |
