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Articles Published Processes
5/14/2026 9:17:12 AM | Browse: 4 | Download: 19
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Received |
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2025-12-30 06:00 |
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Peer-Review Started |
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2025-12-30 06:00 |
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First Decision by Editorial Office Director |
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2026-01-06 07:10 |
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Return for Revision |
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2026-01-06 07:10 |
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Revised |
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2026-01-17 09:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-24 02:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-24 07:54 |
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Articles in Press |
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2026-02-24 07:54 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-28 09:44 |
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Publish the Manuscript Online |
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2026-05-14 09:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Opinion Review |
| Article Title |
Protein induced by vitamin K absence or antagonist-II in hepatocellular carcinoma with normal alpha-fetoprotein: Current advances and controversies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xi-Ming Wang, Hui-Gang Li, Jin-Xin Xu, Xiang Wu and Hong Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hong Li, Full Professor, Li Huili Hospital Affiliated to Ningbo University, No. 57 Xingning Road, Yinzhou District, Ningbo 315000, Zhejiang Province, China. lihong196311@163.com |
| Key Words |
Hepatocellular carcinoma; Alpha-fetoprotein; Protein induced by vitamin K absence/antagonist-II; Des-gamma carboxy prothrombin; Aggressive tumor |
| Core Tip |
We recently read an enlightening study published in the World Journal of Gastrointestinal Oncology that examined the association between PIVKA-II and HCC. The results indicate that PIVKA-II provides additional biological information beyond the conventional biomarker AFP, and is closely associated with aggressive pathological features, including microvascular invasion and increased tumor cell proliferation. Overall, this study supports a shift from single-biomarker measurements toward systems-level risk stratification. Prospective validation remains warranted, and integrating PIVKA-II with imaging-defined tumor burden and vascular invasion risk may better guide surveillance intensity, treatment escalation and transplant-related decision-making. |
| Publish Date |
2026-05-14 09:17 |
| Citation |
Wang XM, Li HG, Xu JX, Wu X, Li H. Protein induced by vitamin K absence or antagonist-II in hepatocellular carcinoma with normal alpha-fetoprotein: Current advances and controversies. World J Gastrointest Oncol 2026; 18(5): 118297 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i5/118297.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i5.118297 |
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