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Publication Name World Journal of Hepatology
Manuscript ID 118303
Country Egypt
Received
2025-12-29 03:07
Peer-Review Started
2025-12-29 03:11
First Decision by Editorial Office Director
2025-12-31 08:19
Return for Revision
2025-12-31 08:19
Revised
2026-01-04 20:50
Publication Fee Transferred
Second Decision by Editor
2026-02-10 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-10 09:34
Articles in Press
2026-02-10 09:34
Edit the Manuscript by Language Editor
2026-02-13 22:01
Typeset the Manuscript
2026-03-30 14:21
Publish the Manuscript Online
2026-05-26 03:52
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Anti-obesity medications, the new frontiers, in metabolic dysfunction-associated fatty liver disease: Efficacy, limitations, and future directions
Manuscript Source Invited Manuscript
All Author List Yasser Fouad, Wafaa A Abdelghany and Reem El Sheemy
ORCID
Author(s) ORCID Number
Yasser Fouad http://orcid.org/0000-0001-7989-5318
Wafaa A Abdelghany http://orcid.org/0000-0002-2536-1334
Reem El Sheemy http://orcid.org/0000-0001-8158-8878
Funding Agency and Grant Number
Corresponding Author Yasser Fouad, Department of Gastroenterology and Endemic Medicine, Faculty of Medicine, Minia University, El Omoumy Road, Minya 61511, Egypt. yasserfouad10@yahoo.com
Key Words Weight regain; Fibrosis; Sarcopenia; Glucagon-like peptide-1; Obesity; Metabolic associated steatohepatitis; Metabolic dysfunction-associated fatty liver disease
Core Tip Novel anti-obesity drugs, especially incretin-based treatments, successfully lower body weight and enhance metabolic dysfunction-associated fatty liver disease indicators like inflammation and steatosis. However, there are major obstacles that limit their long-term potential. These include the frequent recurrence of weight gain following discontinuation, significant side effects, high costs, risks of muscle loss, and inadequate data on fibrosis reversal. In addition to additional research and systemic healthcare reforms to address these limitations, a comprehensive, multidisciplinary approach is necessary to fully realize the potential of these medications for metabolic dysfunction-associated fatty liver disease.
Publish Date 2026-05-26 03:52
Citation

Fouad Y, Abdelghany WA, El Sheemy R. Anti-obesity medications, the new frontiers, in metabolic dysfunction-associated fatty liver disease: Efficacy, limitations, and future directions. World J Hepatol 2026; 18(5): 118303

URL https://www.wjgnet.com/1948-5182/full/v18/i5/118303.htm
DOI https://dx.doi.org/10.4254/wjh.v18.i5.118303
Full Article (PDF) WJH-18-118303-with-cover.pdf
Manuscript File 118303_Auto_Edited_065524.docx
Answering Reviewers 118303-answering-reviewers.pdf
Audio Core Tip 118303-audio.m4a
Conflict-of-Interest Disclosure Form 118303-conflict-of-interest-statement.pdf
Copyright License Agreement 118303-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 118303-non-native-speakers.pdf
Peer-review Report 118303-peer-reviews.pdf
Scientific Misconduct Check 118303-scientific-misconduct-check.png
Scientific Editor Work List 118303-scientific-editor-work-list.pdf
CrossCheck Report 118303-crosscheck-report.pdf