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Articles Published Processes
5/11/2026 9:00:25 AM | Browse: 6 | Download: 11
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Received |
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2025-12-30 01:35 |
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Peer-Review Started |
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2025-12-31 06:26 |
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First Decision by Editorial Office Director |
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2026-02-10 09:18 |
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Return for Revision |
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2026-02-10 09:18 |
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Revised |
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2026-02-11 09:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-04-07 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-07 07:32 |
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Articles in Press |
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2026-04-07 07:32 |
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Edit the Manuscript by Language Editor |
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2026-04-16 18:57 |
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Typeset the Manuscript |
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2026-04-28 15:18 |
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Publish the Manuscript Online |
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2026-05-11 09:00 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Opinion Review |
| Article Title |
When metabolic disease rewrites infection biology: Long-term multiorgan consequences of Helicobacter pylori infection in diabetes
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shree V Dhotre, Pradnya S Dhotre, Arunkumar Rao and Basavraj S Nagoba |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Basavraj S Nagoba, PhD, Professor, Department of Microbiology, Maharashtra Institute of Medical Sciences and Research (Medical College), Vishwanathpuram, Ambajogai Road, Latur 413531, Maharashtra, India. dr_bsnagoba@yahoo.com |
| Key Words |
Helicobacter pylori; Diabetes mellitus; Streptozotocin; Multiorgan pathology; Host-pathogen interaction; Gut microbiota; Virulence factors; Systemic inflammation; Trained immunity; Extra-gastric disease |
| Core Tip |
This long-term experimental study demonstrates that diabetes transforms Helicobacter pylori infection from a largely gastric disease into a systemic pathological modifier. Prolonged colonization, persistent inflammation, extra-gastric dissemination of virulence factors, and compounded disruption of gut microbiota collectively drive irreversible multiorgan injury, even after partial improvement in bacterial load and glycemic status. These findings carry important implications for infection screening, eradication timing, and organ surveillance in diabetic patients, and open novel avenues for therapeutic intervention targeting the inflammation-microbiota-metabolic axis. |
| Publish Date |
2026-05-11 09:00 |
| Citation |
Dhotre SV, Dhotre PS, Rao A, Nagoba BS. When metabolic disease rewrites infection biology: Long-term multiorgan consequences of Helicobacter pylori infection in diabetes. World J Diabetes 2026; 17(5): 118333 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i5/118333.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i5.118333 |
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