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Articles Published Processes
7/9/2026 6:58:21 AM | Browse: 2 | Download: 0
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Received |
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2025-12-30 01:37 |
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Peer-Review Started |
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2026-01-04 12:50 |
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First Decision by Editorial Office Director |
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2026-02-03 08:27 |
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Return for Revision |
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2026-02-03 08:27 |
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Revised |
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2026-02-14 10:23 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-14 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-14 08:05 |
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Articles in Press |
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2026-05-14 08:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-28 03:06 |
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Publish the Manuscript Online |
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2026-07-09 06:58 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Opinion Review |
| Article Title |
Gut-brain axis under attack: Links between diabetes, environmental toxicants, and neurodegeneration
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mostafa M Gouda |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mostafa M Gouda, PhD, Professor, College of Biosystems Engineering and Food Science, Zhejiang University, No. 866 Yuhangtang Road, Hangzhou 310027, Zhejiang Province, China. mostafa-gouda@zju.edu.cn |
| Key Words |
Gut-brain axis; Diabetes mellitus; Heavy metals; Environmental toxicants; Gut microbiota dysbiosis; Neuroinflammation; Oxidative stress |
| Core Tip |
Emerging evidence shows that when diabetes coincides with environmental metal exposure, it significantly impacts the gut-brain axis. Hyperglycemia and toxicants together lead to gut dysbiosis, intestinal barrier breakdown, and increased neuroinflammation. This results in worse cognitive and hippocampal damage than each factor alone. Specific microbiota changes link metabolic toxicity to brain dysfunction, suggesting the need for prevention through reduced exposure and better glycemic control. |
| Publish Date |
2026-07-09 06:58 |
| Citation |
Gouda MM. Gut-brain axis under attack: Links between diabetes, environmental toxicants, and neurodegeneration. World J Diabetes 2026; 17(7): 118334
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| URL |
https://www.wjgnet.com/1948-9358/full/v17/i7/118334.htm |
| DOI |
https://doi.org/10.4239/wjd.118334 |
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