6/24/2026 9:14:01 AM | Browse: 0 | Download: 0
| Publication Name | World Journal of Gastrointestinal Surgery |
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| Manuscript ID | 118336 |
| Country | China |
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| ISSN | 1948-9366 (online) |
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| Open Access | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright | ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 |
| Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 |
| Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website | http://www.wjgnet.com |
| Category | Gastroenterology & Hepatology | ||||||
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| Manuscript Type | Observational Study | ||||||
| Article Title | Correlation and clinical significance of hepcidin and STAT3 in colorectal cancer | ||||||
| Manuscript Source | Unsolicited Manuscript | ||||||
| All Author List | Kang-Bao Li, Qiao-Zhen Hu, Jie Li, Zhong-Yan Li, Kai-Yu Feng, Min Ye, Duo Luo, Xin-Yue Zhang, Shi Zhang and Peng Chen | ||||||
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| Corresponding Author | Peng Chen, PhD, Department of Geriatrics, Gastroenterology Ward, Guangzhou First People’s Hospital, the Second Affiliated Hospital, School of Medicine, South China University of Technology, NO. 1, Panfu Road, Guangzhou 510180, Guangdong Province, China. p2830chenp@sina.com | ||||||
| Key Words | Hepcidin; STAT3; Colorectal cancer; Clinical significance; Lymph node metastasis | ||||||
| Core Tip | Iron metabolism disorders play a pivotal role in colorectal cancer (CRC) development and progression, with this disordered state closely associated with hepcidin and signal transducer and activator of transcription 3 (STAT3) dysregulation. As a vital transcription factor, STAT3, upon activation, translocates to the cell nucleus and directly binds to the hepcidin gene promoter region, thereby upregulating hepcidin expression. Concurrently, CRC cells adapt to iron overload environments by modulating the expression of iron metabolism-related proteins. This study aims to investigate the expression profiling and characteristics of hepcidin and STAT3, iron metabolism indicators, in patients with CRC. | ||||||
| Publish Date | 2026-06-24 09:14 | ||||||
| Citation |
Li KB, Hu QZ, Li J, Li ZY, Feng KY, Ye M, Luo D, Zhang XY, Zhang S, Chen P. Correlation and clinical significance of hepcidin and STAT3 in colorectal cancer. World J Gastrointest Surg 2026; 18(6): 118336 |
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| URL | https://www.wjgnet.com/1948-9366/full/v18/i6/118336.htm | ||||||
| DOI | https://doi.org/10.4240/wjgs.118336 |
| Full Article (PDF) | WJGS-18-118336-with-cover.pdf |
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| STROBE Statement | 118336-STROBE-statement.pdf |
| Manuscript File | 118336_Auto_Edited_091833.docx |
| Answering Reviewers | 118336-answering-reviewers.pdf |
| Audio Core Tip | 118336-audio.m4a |
| Biostatistics Review Certificate | 118336-biostatistics-statement.pdf |
| Conflict-of-Interest Disclosure Form | 118336-conflict-of-interest-statement.pdf |
| Copyright License Agreement | 118336-copyright-assignment.pdf |
| Signed Informed Consent Form(s) or Document(s) | 118336-informed-consent-statement.pdf |
| Institutional Review Board Approval Form or Document | 118336-institutional-review-board-statement.pdf |
| Non-Native Speakers of English Editing Certificate | 118336-non-native-speakers.pdf |
| Peer-review Report | 118336-peer-reviews.pdf |
| Scientific Misconduct Check | 118336-scientific-misconduct-check.png |
| Scientific Editor Work List | 118336-scientific-editor-work-list.pdf |
| CrossCheck Report | 118336-crosscheck-report.pdf |