| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Case Control Study |
| Article Title |
Gut microbiota in a Saudi population with chronic kidney disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Afnan A Almuhanna, Chittibabu Vatte, Qian Guo, Tamer S Elsalamouni, Fahd A Al-Muhanna, Ameen M Aboalrihy, Hassan A Alhabib, Mohammed F Almomen, Rudaynah A Alali, Alawi H Habara, Mohammed A Alrubaish, Kaltham M Alfalah, Cyril Cyrus, Ibrahiem Saeed Abdul-Rahman, Brendan J Keating, Amein K Al-Ali and Chan Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Deanship of scientific Research at Imam Abdulrahman Bin Faisal University |
No. 2020-182-MED |
|
| Corresponding Author |
Amein K Al-Ali, PhD, Professor, Department of Clinical Biochemistry, Imam Abdulrahman Bin Faisal University, Building A72, Dammam 31441, Saudi Arabia. aalali@iau.edu.sa |
| Key Words |
Chronic kidney disease; Hemodialysis; Peritoneal dialysis; Microbiota; Saudi; Microbiota |
| Core Tip |
In a Saudi cohort, the gut microbiota clearly differed between controls, chronic kidney disease patients, and patients on hemodialysis (HD) or peritoneal dialysis (PD). Simple microbial risk scores (area under the curve > 0.9) accurately distinguished chronic kidney disease patients, HD patients, and PD patients from controls, suggesting its potential as a noninvasive biomarker. The PD microbiota was characterized by reduced diversity, increased abundance of Proteobacteria and virulence factors, weaker microbial networks, and a proinflammatory profile. In contrast, partial restoration of a healthier microbiome was observed in HD patients, with increased short-chain fatty acid production and reduced lipopolysaccharide biosynthesis, indicating dialysis modality-specific effects on the gut microbiome and potential targets for microbiome-based interventions. |
| Publish Date |
2026-06-15 08:38 |
| Citation |
Almuhanna AA, Vatte C, Guo Q, Elsalamouni TS, Al-Muhanna FA, Aboalrihy AM, Alhabib HA, Almomen MF, Alali RA, Habara AH, Alrubaish MA, Alfalah KM, Cyrus C, Abdul-Rahman IS, Keating BJ, Al-Ali AK, Wang C. Gut microbiota in a Saudi population with chronic kidney disease. World J Nephrol 2026; 15(2): 118343
|
| URL |
https://www.wjgnet.com/2220-6124/full/v15/i2/118343.htm |
| DOI |
https://doi.org/10.5527/wjn.v15.i2.118343 |
