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Articles Published Processes
5/20/2026 8:53:14 AM | Browse: 1 | Download: 0
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Received |
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2025-12-30 06:07 |
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Peer-Review Started |
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2025-12-30 06:07 |
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First Decision by Editorial Office Director |
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2026-01-06 09:51 |
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Return for Revision |
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2026-01-06 09:51 |
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Revised |
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2026-01-10 07:49 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-09 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-09 08:31 |
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Articles in Press |
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2026-03-09 08:31 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-30 14:09 |
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Publish the Manuscript Online |
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2026-05-20 08:53 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Prospective Study |
| Article Title |
Clinicopathological and prognostic relevance of nestin in low- and high-grade gliomas: An immunohistochemical study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sabeen Nasir, Asif Ali, Ihsan Ullah, Shabnam Wazir, Irum Javaid, Summaya Z Jalal, Ishaq Khan and Muhammed Mubarak |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com |
| Key Words |
Low-grade glioma; High-grade glioma; Cytoskeletal protein nestin; Survival analysis; Tumour grade |
| Core Tip |
Gliomas show marked biological heterogeneity, necessitating accessible prognostic biomarkers, especially in resource-limited settings. This prospective study demonstrates that nestin overexpression is significantly associated with higher tumour grade and inferior overall survival in both low- and high-grade gliomas. High-grade tumours showed markedly increased nestin expression and substantially shorter survival compared to low-grade counterparts. Patients with high nestin expression experienced poorer outcomes, while the combined analysis revealed the worst prognosis in high-grade gliomas with high nestin levels. These findings highlight nestin as a practical supplementary prognostic marker that may aid risk stratification where advanced molecular testing is unavailable. |
| Publish Date |
2026-05-20 08:53 |
| Citation |
Nasir S, Ali A, Ullah I, Wazir S, Javaid I, Jalal SZ, Khan I, Mubarak M. Clinicopathological and prognostic relevance of nestin in low- and high-grade gliomas: An immunohistochemical study. World J Clin Oncol 2026; 17(5): 118350 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i5/118350.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i5.118350 |
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