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7/13/2026 9:40:24 AM | Browse: 1 | Download: 1
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 118400
Country Sweden
Received
2025-12-31 02:42
Peer-Review Started
2025-12-31 02:44
First Decision by Editorial Office Director
2026-01-14 02:55
Return for Revision
2026-01-14 02:55
Revised
2026-01-28 00:50
Publication Fee Transferred
2026-02-09 11:45
Second Decision by Editor
2026-04-08 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-04-08 08:05
Articles in Press
2026-04-08 08:05
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-26 05:07
Publish the Manuscript Online
2026-07-13 09:40
ISSN 1948-5204 (online)
Open Access This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Retrospective Cohort Study
Article Title Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy
Manuscript Source Unsolicited Manuscript
All Author List Nader Algethami, Valentinus Valdimarsson, Victor Verwaal and Ingvar Syk
ORCID
Author(s) ORCID Number
Nader Algethami http://orcid.org/0009-0007-9564-0965
Funding Agency and Grant Number
Corresponding Author Nader Algethami, MD, Department of Surgery, Skane University Hospital, Inga Marie Nilssons gata 38, Malmo 21428, Skane, Sweden. nader.algethami@med.lu.se
Key Words Hyperthermic intraperitoneal chemotherapy; Peritoneal carcinomatosis; Peritoneal surface malignancy; Oxaliplatin; Acute kidney injury; Sodium thiosulfate
Core Tip This retrospective single-center study demonstrates that prophylactic sodium thiosulfate (ST) markedly reduces both the incidence and severity of acute kidney injury in patients undergoing cytoreductive surgery with oxaliplatin-based hyperthermic intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis. Patients receiving ST showed significantly lower postoperative creatinine levels and fewer kidney injuries without an increased risk of other postoperative complications. These findings indicate a clear nephroprotective benefit in this setting and support consideration of ST in oxaliplatin-based hyperthermic intraperitoneal chemotherapy protocols, although future prospective studies are warranted to confirm these results.
Publish Date 2026-07-13 09:40
Citation

Algethami N, Valdimarsson V, Verwaal V, Syk I. Prophylactic sodium thiosulfate reduces the risk and severity of acute kidney injury in oxaliplatin-based hyperthermic intraperitoneal chemotherapy. World J Gastrointest Oncol 2026; 18(7): 118400

URL https://www.wjgnet.com/1948-5204/full/v18/i7/118400.htm
DOI https://doi.org/10.4251/wjgo.v18.i7.118400
Full Article (PDF) WJGO-18-118400-with-cover.pdf
STROBE Statement 118400-STROBE-statement.pdf
Manuscript File 118400_Auto_Edited_093525.docx
Answering Reviewers 118400-answering-reviewers.pdf
Audio Core Tip 118400-audio.mp3
Biostatistics Review Certificate 118400-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 118400-conflict-of-interest-statement.pdf
Copyright License Agreement 118400-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 118400-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 118400-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 118400-non-native-speakers.pdf
Supplementary Material 118400-supplementary-material.pdf
Peer-review Report 118400-peer-reviews.pdf
Scientific Misconduct Check 118400-scientific-misconduct-check.png
Scientific Editor Work List 118400-scientific-editor-work-list.pdf
CrossCheck Report 118400-crosscheck-report.pdf