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Articles Published Processes
5/21/2026 7:49:50 AM | Browse: 1 | Download: 0
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Received |
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2026-01-02 13:49 |
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Peer-Review Started |
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2026-01-02 13:52 |
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First Decision by Editorial Office Director |
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2026-01-08 07:53 |
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Return for Revision |
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2026-01-08 07:53 |
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Revised |
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2026-01-22 07:26 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-26 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-26 03:48 |
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Articles in Press |
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2026-02-26 03:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-29 02:59 |
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Publish the Manuscript Online |
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2026-05-21 07:49 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Minireviews |
| Article Title |
Metabolic footprint of sepsis and septic shock: A narrative review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anjali Mishra and Deven Juneja |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Deven Juneja, Director, MD, Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, 1 Press Enclave Road, New Delhi 110017, India. devenjuneja@gmail.com |
| Key Words |
Septic shock; Sepsis; Systemic inflammatory response syndrome; Metabolomics; Biomarkers |
| Core Tip |
Sepsis remains a cause of significant morbidity and mortality despite recent advances. Moreover, patient’s response to therapy and clinical prognosis is often difficult to accurately predict. Given the heterogeneous and multifactorial nature of disease, broad therapeutic approaches often fail to reduce mortality. Thus, there is a critical need for a better understanding of these complex, multifactorial conditions driven by diverse biological insults and causes. Biomarkers such as procalcitonin, presepsin, interleukin-6, and C-reactive protein are frequently used in diagnosing and monitoring sepsis, but they are far from ideal. Human metabolic activity is extremely sensitive to the surrounding microenvironment, with metabolite profiles reflecting combined influences from transcriptional, translational, and environmental factors. Hence, metabolites are a highly promising class of biomarkers which may be exploited to detect disease presence, progression, and therapeutic response. Emerging data suggests that early introduction of metabolomic data into routine critical care practice may enable more precise severity identification, targeted therapeutic strategies, and improved outcomes for patients with sepsis and septic shock. |
| Publish Date |
2026-05-21 07:49 |
| Citation |
Mishra A, Juneja D. Metabolic footprint of sepsis and septic shock: A narrative review. World J Crit Care Med 2026; 15(2): 118428 |
| URL |
https://www.wjgnet.com/2220-3141/full/v15/i2/118428.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v15.i2.118428 |
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