| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Impairment of the intestinal epithelium barrier through alteration of proliferation and differentiation balance in alcohol use disorder
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ami G Toulehohoun, Jérôme Ambroise, Bouchra Illiyas, Luca Maccioni, Joaquim Lupianez, Rita Manco, Laure-Alix Clerbaux, Caroline Bouzin, Bernd Schnabl and Peter Stärkel |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fond National de Recherche Scientifique Belgium |
No. T.0217.18, No. J.0195.24, and No. T.0195.22 |
| Action de Recherche Concertée, Université Catholique de Louvain, Belgium by National Institutes of Health |
No. 5R01AA024726-08, No. 5R01AA020703-05 |
| Action de Recherche Concertée, Université Catholique de Louvain, Belgium by National Institutes of Health |
No. 5U01AA026939-05, No. 1R01AA031710-01A1 |
| Action de Recherche Concertée, Université Catholique de Louvain, Belgium by National Institutes of Health |
No. 5P30DK120515-07 |
|
| Corresponding Author |
Ami G Toulehohoun, Laboratory of Gastroenterology (GAEN), Institut de Recherche Expérimentale et Clinique, UCLouvain, Avenue Mounier 52, Brussels 1200, Belgium. ami.toulehohoun@uclouvain.be |
| Key Words |
Alcohol use disorder; Intestinal epithelium; Intestinal barrier; Stem cell niche; Intestinal organoids; Enteroids |
| Core Tip |
The effects of alcohol on the human intestinal epithelium are poorly understood, as existing studies are limited, inconsistent, and largely based on animal models that incompletely reflect human pathology. Human-based analyses reveal that heavy alcohol consumption disrupts intestinal epithelial homeostasis by altering stem cell niche and lineage commitment. Duodenal crypts displayed increased depth and expanded proliferation driven by enlarged OLFM4+ stem-like compartments and elevated Ki67+ and CD44+ cells. Ethanol induced aberrant proliferation, impaired secretory lineage commitment, antimicrobial defense and nutrient transport. Using human intestinal organoids, we confirm a direct, Wnt-independent proliferative effect of ethanol on epithelial cells. |
| Publish Date |
2026-07-14 09:34 |
| Citation |
Toulehohoun AG, Ambroise J, Illiyas B, Maccioni L, Lupianez J, Manco R, Clerbaux LA, Bouzin C, Schnabl B, Stärkel P. Impairment of the intestinal epithelium barrier through alteration of proliferation and differentiation balance in alcohol use disorder. World J Gastroenterol 2026; 32(28): 118458
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i28/118458.htm |
| DOI |
https://doi.org/10.3748/wjg.118458 |
