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Articles Published Processes
5/26/2026 3:52:09 AM | Browse: 0 | Download: 0
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Received |
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2026-01-09 07:01 |
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Peer-Review Started |
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2026-01-09 07:01 |
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First Decision by Editorial Office Director |
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2026-01-14 08:07 |
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Return for Revision |
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2026-01-14 08:07 |
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Revised |
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2026-01-28 05:33 |
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Publication Fee Transferred |
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2026-02-02 10:25 |
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Second Decision by Editor |
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2026-02-26 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-26 05:20 |
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Articles in Press |
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2026-02-26 05:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-14 05:03 |
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Publish the Manuscript Online |
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2026-05-26 03:52 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Ten-year enzyme replacement therapy in early childhood-onset lysosomal acid lipase deficiency: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Irem Kaplan, Deniz Kor, Fatma D Bulut, Gokhan Tumgor, Derya Alabaz and Neslihan Önenli Mungan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Irem Kaplan, MD, Department of Pediatric Metabolism and Nutrition, Cukurova University Faculty of Medicine, Balcalı Campus, Adana 01330, Türkiye. kaplani@cu.edu.tr |
| Key Words |
Cholesteryl ester storage diseases; Wolman disease; Enzyme replacement treatment; Sebelipase alfa; Lysosomal acid lipase deficiency; Lysosomal storage disorders; Case report |
| Core Tip |
Early diagnosis of lysosomal acid lipase deficiency (LAL-D) is challenging owing to its nonspecific clinical presentation. We report a rare case diagnosed before the age of 4 years, with long-term follow-up after early initiation of enzyme replacement therapy. Our patient showed marked improvements in growth, liver function, and histology over 10 years, with no treatment-related adverse events. This case highlights the importance of early recognition and timely treatment of LAL-D to optimize long-term outcomes in affected children. |
| Publish Date |
2026-05-26 03:52 |
| Citation |
Kaplan I, Kor D, Bulut FD, Tumgor G, Alabaz D, Önenli Mungan N. Ten-year enzyme replacement therapy in early childhood-onset lysosomal acid lipase deficiency: A case report. World J Hepatol 2026; 18(5): 118469 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i5/118469.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i5.118469 |
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