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Articles Published Processes
8/4/2026 7:19:46 AM | Browse: 1 | Download: 0
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Received |
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2026-01-04 07:43 |
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Peer-Review Started |
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2026-01-04 07:44 |
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First Decision by Editorial Office Director |
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2026-01-26 09:08 |
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Return for Revision |
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2026-01-26 09:08 |
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Revised |
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2026-03-31 11:14 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-25 02:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-25 09:49 |
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Articles in Press |
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2026-05-25 09:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-28 00:36 |
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Publish the Manuscript Online |
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2026-08-04 07:19 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
H3K18 La-METTL5-CCT2 signaling axis promotes colorectal cancer progression by inhibiting pyroptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Peng Wang, Chang Liu, Hao-Wen Zhang, Jing-Ming Zhai, Jia-Xin Zhu, Guan-Duo Sun, Ya-Hang An, Hai-Jun Yang, Dong-Shuai Jing and De-Chun Liu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Henan Province Science and Technology Research Project |
232102310043 |
| Henan Provincial Science and Technology Research and Development Plan Joint Fund Project |
222103810047 |
| Key Scientific Research Project Plan of Colleges and Universities in Henan Province |
22A320033 |
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| Corresponding Author |
De-Chun Liu, PhD, Department of Gastrointestinal Surgery, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, No. 24 Jinghua Road, Jianxi District, Luoyang 471003, Henan Province, China. lydocliu666@163.com |
| Key Words |
Colorectal cancer; Histone lactylation; H3K18 La; METTL5; CCT2; Pyroptosis; M6A methylation; Lactate |
| Core Tip |
Lactate-induced histone H3K18 lactylation drives colorectal cancer progression by activating METTL5 transcription. METTL5 stabilizes CCT2 mRNA via m6A modification, upregulating CCT2 expression and inhibiting pyroptosis. This H3K18 lactylation-METTL5-CCT2 signaling axis links metabolic reprogramming, epigenetics, and RNA methylation to suppress cell death and promote malignancy. Targeting this pathway with the PI3Kβ inhibitor AZD6482 increases oxaliplatin cytotoxicity in high-lactate microenvironments, offering a novel therapeutic strategy for colorectal cancer. |
| Publish Date |
2026-08-04 07:19 |
| Citation |
Wang XP, Liu C, Zhang HW, Zhai JM, Zhu JX, Sun GD, An YH, Yang HJ, Jing DS, Liu DC. H3K18 La-METTL5-CCT2 signaling axis promotes colorectal cancer progression by inhibiting pyroptosis. World J Gastroenterol 2026; 32(31): 118472
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i31/118472.htm |
| DOI |
https://doi.org/10.3748/wjg.118472 |
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