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Articles Published Processes
5/13/2026 8:18:27 AM | Browse: 8 | Download: 45
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Received |
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2026-01-04 05:45 |
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Peer-Review Started |
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2026-01-04 05:46 |
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First Decision by Editorial Office Director |
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2026-01-21 08:49 |
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Return for Revision |
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2026-01-21 08:49 |
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Revised |
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2026-01-23 16:45 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-26 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-26 03:28 |
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Articles in Press |
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2026-02-26 03:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-16 09:45 |
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Publish the Manuscript Online |
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2026-05-13 08:18 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Review |
| Article Title |
Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mohammed Al-Beltagi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mohammed Al-Beltagi, Chairman, Consultant, Head, MD, PhD, Professor, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mbelrem@hotmail.com |
| Key Words |
Autism regression; Neurodevelopment; Early intervention; Neuroplasticity; Synaptic pruning; Mitochondrial dysfunction; Gut-brain axis |
| Core Tip |
Autism regression, affecting up to one-third of children with autism spectrum disorder, represents a sudden loss of previously acquired social, communicative, or language skills, typically between 12 months and 30 months. This review synthesizes recent evidence, framing regression as a biologically grounded neurodevelopmental event driven by dysregulation of synaptic pruning, excitatory-inhibitory imbalance, neuroinflammation, and disturbances of the mitochondrial or gut-brain axis. Early identification of subtle pre-regression signs, combined with a two-track clinical approach—rapid medical evaluation and immediate initiation of evidence-based therapies such as naturalistic developmental behavioral interventions and parent-mediated interventions—can harness neuroplasticity, promote functional skill recovery, and optimize long-term developmental outcomes. |
| Publish Date |
2026-05-13 08:18 |
| Citation |
Al-Beltagi M. Enigma of autism regression mechanistic pathways, clinical phenotypes, and early intervention implications. World J Clin Pediatr 2026; 15(2): 118495 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i2/118495.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i2.118495 |
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