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Articles Published Processes
6/9/2026 9:23:52 AM | Browse: 0 | Download: 0
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Received |
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2026-01-04 08:36 |
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Peer-Review Started |
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2026-01-04 08:45 |
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First Decision by Editorial Office Director |
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2026-01-14 02:58 |
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Return for Revision |
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2026-01-14 02:58 |
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Revised |
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2026-02-02 18:51 |
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Publication Fee Transferred |
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2026-02-05 18:47 |
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Second Decision by Editor |
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2026-02-27 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-27 07:00 |
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Articles in Press |
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2026-02-27 07:00 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-07 10:17 |
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Publish the Manuscript Online |
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2026-06-09 09:23 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Post-translational modifications in hepatocellular carcinoma: Linking senescence, metabolic reprogramming, and immune evasion for therapeutic innovation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tai-Xian Song, Yao Rong, Hao-Min Ji and Xing-Sheng Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xing-Sheng Wang, Professor, Department of Gastroenterology, Baiyin First People’s Hospital, No. 83 Chang’an Road, Baiyin District, Baiyin 730900, Gansu Province, China. 13227828908@163.com |
| Key Words |
Hepatocellular carcinoma; Post-translational modifications; Cellular senescence; Tumor immune microenvironment; Metabolic reprogramming; Immunotherapy; Single-cell multi-omics; Spatial transcriptomics; Therapy resistance; Precision medicine |
| Core Tip |
Post translational modifications (PTMs) constitute a dynamic regulatory network that critically shapes cellular senescence and the immunosuppressive microenvironment in hepatocellular carcinoma. Key metabolism-linked PTMs such as O-GlcNAcylation and histone lactylation couple glycolytic reprogramming with epigenetic remodeling, driving therapy resistance and immune evasion. Emerging single-cell and spatial multi-omics reveal spatially organized senescence-immune-metabolic niches, providing a basis for multidimensional stratification. This review proposes a sequential “induce-remodel-clear” therapeutic framework, integrating precise senescence induction, PTM-targeted modulation, and enhanced immune clearance to overcome resistance and advance precision hepatocellular carcinoma therapy. |
| Publish Date |
2026-06-09 09:23 |
| Citation |
Song TX, Rong Y, Ji HM, Wang XS. Post-translational modifications in hepatocellular carcinoma: Linking senescence, metabolic reprogramming, and immune evasion for therapeutic innovation. World J Gastrointest Oncol 2026; 18(6): 118497
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| URL |
https://www.wjgnet.com/1948-5204/full/v18/i6/118497.htm |
| DOI |
https://doi.org/10.4251/wjgo.v18.i6.118497 |
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