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9/4/2026 5:57:42 AM | Browse: 1 | Download: 0
Publication Name World Journal of Diabetes
Manuscript ID 118504
Country China
Received
2026-01-04 01:39
Peer-Review Started
2026-01-04 09:35
First Decision by Editorial Office Director
2026-01-19 07:31
Return for Revision
2026-01-19 07:31
Revised
2026-01-26 15:37
Publication Fee Transferred
Second Decision by Editor
2026-03-06 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-06 02:57
Articles in Press
2026-03-06 02:57
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-08-10 10:00
Publish the Manuscript Online
2026-09-04 05:57
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Integrative & Complementary Medicine
Manuscript Type Correspondence
Article Title Letter to the Editor: From acupoint stimulation to immunometabolic regulation: What does electroacupuncture frequency really encode in diabetic gastroparesis?
Manuscript Source Invited Manuscript
All Author List Ke-Jia Li, Yong-Wei Yu and Yang Xia
ORCID
Author(s) ORCID Number
Yong-Wei Yu http://orcid.org/0000-0001-8319-7707
Funding Agency and Grant Number
Corresponding Author Yong-Wei Yu, Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. yuyongwei@zju.edu.cn
Key Words Electroacupuncture frequency; Neuromodulation; Diabetic gastroparesis; Neuroimmune interaction; Immunometabolic regulation
Core Tip Electroacupuncture (EA) exerts therapeutic effects beyond local acupoint stimulation. This letter proposes that stimulation frequency encodes distinct neuromodulatory information that reshapes neuroimmune and immunometabolic regulation in diabetic gastroparesis. By reframing high-frequency EA as a frequency-encoded neuromodulatory strategy rather than a nonspecific peripheral intervention, we highlight how neural signaling may secondarily attenuate inflammatory pathways such as macrophage pyroptosis. This conceptual framework bridges traditional acupuncture with modern neuromodulation science and offers a rational basis for optimizing EA protocols in diabetes-associated gastrointestinal dysfunction. Importantly, this neuromodulatory interpretation is hypothesis-generating and intended to complement, rather than replace, other plausible mechanisms, including local tissue activation and perfusion-related effects.
Publish Date 2026-09-04 05:57
Citation

Li KJ, Yu YW, Xia Y. Letter to the Editor: From acupoint stimulation to immunometabolic regulation: What does electroacupuncture frequency really encode in diabetic gastroparesis? World J Diabetes 2026; 17(9): 118504

URL https://www.wjgnet.com/1948-9358/full/v17/i9/118504.htm
DOI https://doi.org/10.4239/wjd.118504
Full Article (PDF) WJD-17-118504-with-cover.pdf
Manuscript File 118504_Auto_Edited_011534.docx
Answering Reviewers 118504-answering-reviewers.pdf
Audio Core Tip 118504-audio.mp3
Conflict-of-Interest Disclosure Form 118504-conflict-of-interest-statement.pdf
Copyright License Agreement 118504-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 118504-non-native-speakers.pdf
Peer-review Report 118504-peer-reviews.pdf
Scientific Misconduct Check 118504-scientific-misconduct-check.png
CrossCheck Report 118504-crosscheck-report.pdf