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Publication Name World Journal of Gastroenterology
Manuscript ID 118538
Country China
Received
2026-01-07 06:40
Peer-Review Started
2026-01-07 06:41
First Decision by Editorial Office Director
2026-02-13 07:43
Return for Revision
2026-02-13 07:43
Revised
2026-02-14 07:38
Publication Fee Transferred
Second Decision by Editor
2026-03-05 02:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-03-05 09:13
Articles in Press
2026-03-05 09:13
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-06-04 06:16
Publish the Manuscript Online
2026-06-12 10:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Opinion Review
Article Title Tumor laterality in primary intestinal diffuse large B-cell lymphoma: A prognostic leap or an anatomical mirage?
Manuscript Source Unsolicited Manuscript
All Author List Shi-Qiong Zhou, Chao-Qun Zhou and Qing-Hua Ke
ORCID
Author(s) ORCID Number
Shi-Qiong Zhou http://orcid.org/0009-0000-5619-2978
Chao-Qun Zhou http://orcid.org/0009-0009-8758-1189
Qing-Hua Ke http://orcid.org/0009-0003-3582-3824
Funding Agency and Grant Number
Corresponding Author Qing-Hua Ke, Chief Physician, PhD, Department of Chemoradiotherapy, Jingzhou No. 1 People's Hospital and First Affiliated Hospital of Yangtze University, No. 10 Tianhu Road, Shashi District, Jingzhou 434000, Hubei Province, China. 3803354759@qq.com
Key Words Primary intestinal diffuse large B-cell lymphoma; Tumor laterality; Prognosis; Nomogram; International Prognostic Index
Core Tip The observation that left-sided primary intestinal diffuse large B-cell lymphoma (PI-DLBCL) carries a worse prognosis than right-sided disease introduces a novel anatomical paradigm into lymphoma risk stratification. While intriguing, this finding's clinical utility is currently limited by modest effect sizes and a lack of mechanistic understanding. This review argues that tumor laterality is best viewed not as an immediate treatment-guiding tool, but as a powerful lens through which to explore the spatial biology of PI-DLBCL. Future research must move beyond anatomical correlation to elucidate the underlying microbiomic, immunologic, and molecular drivers, paving the way for truly personalized therapeutic strategies.
Publish Date 2026-06-12 10:39
Citation

Zhou SQ, Zhou CQ, Ke QH. Tumor laterality in primary intestinal diffuse large B-cell lymphoma: A prognostic leap or an anatomical mirage? World J Gastroenterol 2026; 32(24): 118538

URL https://www.wjgnet.com/1007-9327/full/v32/i24/118538.htm
DOI https://doi.org/10.3748/wjg.118538
Full Article (PDF) WJG-32-118538-with-cover.pdf
Manuscript File 118538_Auto_Edited_023547.docx
Answering Reviewers 118538-answering-reviewers.pdf
Audio Core Tip 118538-audio.wav
Conflict-of-Interest Disclosure Form 118538-conflict-of-interest-statement.pdf
Copyright License Agreement 118538-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 118538-non-native-speakers.pdf
Peer-review Report 118538-peer-reviews.pdf
Scientific Misconduct Check 118538-scientific-misconduct-check.png
Scientific Editor Work List 118538-scientific-editor-work-list.pdf
CrossCheck Report 118538-crosscheck-report.pdf