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Publication Name World Journal of Orthopedics
Manuscript ID 118547
Country Egypt
Received
2026-01-05 07:09
Peer-Review Started
2026-01-05 07:11
First Decision by Editorial Office Director
2026-01-16 06:30
Return for Revision
2026-01-16 06:30
Revised
2026-01-29 21:34
Publication Fee Transferred
Second Decision by Editor
2026-02-27 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-27 03:52
Articles in Press
2026-02-27 03:52
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-04-28 07:58
Publish the Manuscript Online
2026-05-18 08:33
ISSN 2218-5836 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Observational Study
Article Title In knee osteoarthritis, what is the knee deformity threshold after which the ankle realigns beyond the neutral zone?
Manuscript Source Invited Manuscript
All Author List Ahmed A Khalifa, Shikuria Lemma and Amr A Fadle
ORCID
Author(s) ORCID Number
Ahmed A Khalifa http://orcid.org/0000-0002-0710-6487
Shikuria Lemma http://orcid.org/0000-0002-7810-3945
Amr A Fadle http://orcid.org/0000-0002-4032-6254
Funding Agency and Grant Number
Corresponding Author Ahmed A Khalifa, Assistant Professor, FRCS, MD, Department of Orthopaedic, Qena Faculty of Medicine and University Hospital, South Valley University, Kilo 6 Qena-Safaga Highway, Qena 83523, Qina, Egypt. ahmed_adel0391@med.svu.edu.eg
Key Words Knee alignment; Ankle alignment; Varus deformity; Valgus deformity; Coronal plane; Knee osteoarthritis
Core Tip We investigated 845 lower limbs with primary knee osteoarthritis (OA) and detected an association between knee deformity and ankle joint alignment in the coronal plane. Varus knee alignment was the most commonly occurring and was strongly associated with varus ankle alignment, whereas valgus knees showed heterogeneous ankle adaptation. The hip to knee to ankle angle (HKAA) and the tibiotalar angle were moderately correlated, with knee alignment as the significant determinant of ankle alignment, independent of age and sex. OA severity (Kellgren-Lawrence grades) was associated with progressively greater varus alignment at the knee and ankle. The ankle joint will align beyond the accepted neutral range at specific HKAA thresholds of approximately 175.7° and 189.2° for varus and valgus knee deformity, respectively. These thresholds were consistent across sex and OA severity, underscoring the primacy of coronal knee alignment in driving ankle compensation.
Publish Date 2026-05-18 08:33
Citation

Khalifa AA, Lemma S, Fadle AA. In knee osteoarthritis, what is the knee deformity threshold after which the ankle realigns beyond the neutral zone? World J Orthop 2026; 17(5): 118547

URL https://www.wjgnet.com/2218-5836/full/v17/i5/118547.htm
DOI https://dx.doi.org/10.5312/wjo.v17.i5.118547
Full Article (PDF) WJO-17-118547-with-cover.pdf
STROBE Statement 118547-STROBE-statement.pdf
Manuscript File 118547_Auto_Edited_055644.docx
Answering Reviewers 118547-answering-reviewers.pdf
Audio Core Tip 118547-audio.mp3
Biostatistics Review Certificate 118547-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 118547-conflict-of-interest-statement.pdf
Copyright License Agreement 118547-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 118547-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 118547-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 118547-non-native-speakers.pdf
Peer-review Report 118547-peer-reviews.pdf
Scientific Misconduct Check 118547-scientific-misconduct-check.png
Scientific Editor Work List 118547-scientific-editor-work-list.pdf
CrossCheck Report 118547-crosscheck-report.pdf