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Articles Published Processes
7/24/2026 10:16:19 AM | Browse: 2 | Download: 0
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Received |
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2026-02-03 10:02 |
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Peer-Review Started |
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2026-02-03 10:02 |
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First Decision by Editorial Office Director |
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2026-03-03 07:27 |
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Return for Revision |
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2026-03-03 07:27 |
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Revised |
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2026-03-18 02:49 |
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Publication Fee Transferred |
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2026-03-20 01:47 |
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Second Decision by Editor |
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2026-05-27 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-27 07:45 |
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Articles in Press |
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2026-05-27 07:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-24 10:14 |
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Publish the Manuscript Online |
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2026-07-24 10:16 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
miR-140-3p in exosomes derived from bone-marrow mesenchymal stem cells inhibits pyrotoisosis by targeting PTEN under high-glucose condition
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Wu, Wen-Hui Yin, Hong-Jing Wang and Hui Cai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Gansu Province |
22JR5RA692 |
| Lanzhou Youth Scientific and Technological Talent Innovation Project |
2024-QN-38 |
| Backbone and Young Talent Project for Provincial Health Commission |
GSWSQN2025-20 |
| National Natural Science Foundation of China |
82360498 |
| Gansu Joint Scientific Research Fund Major Project |
23JRRA1537 |
| Central-Guided Local Science and Technology Development Found |
25ZYJA003 |
| Alpha Isotope Mass Production Technology and Targeted Radiopharmaceuticals Research |
GSTWS250108 |
| Gansu Provincial Clinical Medical Research Center for Burn and Wound Repair |
21JR7RA674 |
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| Corresponding Author |
Hui Cai, The First Clinical Medical School, Lanzhou University, No. 222 Tianshui South Road, Chengguan District, Lanzhou 730000, Gansu Province, China. caialongteams@163.com |
| Key Words |
Bone marrow mesenchymal stem cell-derived exosomes; Rat fibroblasts; MicroRNA; Phosphatase and tensin homolog; Pyroptosis |
| Core Tip |
Specifically, extracellular vesicles derived from bone marrow mesenchymal stem cells contain miR-140-3p that inhibits pyroptosis in rat dermal fibroblasts caused by hyperglycaemic stimulation through direct inhibition of phosphatase and tensin homolog. By blocking the NLRP3/caspase-1/gasdermine-D-N-terminal-dependent pyroptosis pathway to promote fibroblast proliferation and migration. The miR-140-3p/phosphatase and tensin homolog axis has provided an attractive strategy to treat diabetic foot ulcers. |
| Publish Date |
2026-07-24 10:16 |
| Citation |
Wu Y, Yin WH, Wang HJ, Cai H. miR-140-3p in exosomes derived from bone-marrow mesenchymal stem cells inhibits pyrotoisosis by targeting PTEN under high-glucose condition. World J Stem Cells 2026; 18(7): 118557
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i7/118557.htm |
| DOI |
https://doi.org/10.4252/wjsc.118557 |
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