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Articles Published Processes
6/30/2026 1:35:09 PM | Browse: 1 | Download: 0
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Received |
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2026-01-06 06:24 |
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Peer-Review Started |
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2026-01-06 06:26 |
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First Decision by Editorial Office Director |
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2026-02-04 09:59 |
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Return for Revision |
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2026-02-04 09:59 |
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Revised |
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2026-02-14 11:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-28 02:32 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-28 07:08 |
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Articles in Press |
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2026-02-28 07:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-24 07:05 |
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Publish the Manuscript Online |
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2026-06-30 13:35 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Editorial |
| Article Title |
Resetting the fibrotic liver clock: NR1D1 couples Hedyotis diffusa to the HIF-1/urea-cycle-ammonia axis and stellate cell activation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Si-Rui Wang, Xin-Yu Lu, Guo-Ju Jin, Ting-Lan Cao and Hui-Zhong Jiang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hui-Zhong Jiang, PhD, Professor, Researcher, Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 11 North Third Ring Road East, Beijing 100700, China. jianghz93@126.com |
| Key Words |
Circadian rhythm; NR1D1; HIF-1 signaling; Urea cycle; Hepatic stellate cell activation; Hedyotis diffusa injection |
| Core Tip |
Hepatic fibrosis is a pivotal and potentially reversible stage of chronic liver disease, yet approved antifibrotic therapies remain scarce. Xia et al propose that Hedyotis diffusa injection mitigates fibrogenesis by engaging the core clock gene NR1D1, with two downstream branches—suppression of HIF-1 signaling and restoration of urea-cycle/ammonia homeostasis—converging on reduced hepatic stellate cell activation and collagen deposition. This work connects circadian regulation with hypoxia responses and nitrogen metabolism, addressing a key mechanistic gap in liver scarring. By highlighting a druggable clock node and clinically accessible metabolic readouts, it may inform clock-guided antifibrotic development and biomarker-based staging and response monitoring. |
| Publish Date |
2026-06-30 13:35 |
| Citation |
Wang SR, Lu XY, Jin GJ, Cao TL, Jiang HZ. Resetting the fibrotic liver clock: NR1D1 couples Hedyotis diffusa to the HIF-1/urea-cycle-ammonia axis and stellate cell activation. World J Gastroenterol 2026; 32(25): 118561
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i25/118561.htm |
| DOI |
https://doi.org/10.3748/wjg.118561 |
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