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Publication Name World Journal of Diabetes
Manuscript ID 118576
Country China
Received
2026-01-06 05:40
Peer-Review Started
2026-01-06 07:06
First Decision by Editorial Office Director
2026-02-10 09:19
Return for Revision
2026-02-10 09:19
Revised
2026-02-22 11:19
Publication Fee Transferred
Second Decision by Editor
2026-04-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-04-15 10:16
Articles in Press
2026-04-15 10:16
Edit the Manuscript by Language Editor
2026-04-23 18:51
Typeset the Manuscript
2026-05-13 15:37
Publish the Manuscript Online
2026-06-11 11:23
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Opinion Review
Article Title Improving intraoperative perfusion reliability in anterolateral thigh free flap reconstruction for diabetic foot ulcers
Manuscript Source Unsolicited Manuscript
All Author List Peng-Yu Lu, Zhuang-Yu Hao, Guang-Wei Xing, Peng-Fei Zhang, Yan-Song Liu, Wen-Yang Li and Ming-Jie Xu
ORCID
Author(s) ORCID Number
Peng-Yu Lu http://orcid.org/0009-0006-4288-5208
Ming-Jie Xu http://orcid.org/0009-0002-2212-6774
Funding Agency and Grant Number
Funding Agency Grant Number
the 2023 Henan Provincial Medical Science and Technology Research Program (Joint Co-construction Project) LHGJ20230409
Corresponding Author Ming-Jie Xu, Head, MD, Professor, First Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, No.3 Kangfuqian Street, Erqi District, Zhengzhou 450052, Henan Province, China. 65727257@qq.com
Key Words Anterolateral thigh flap; Diabetic foot ulcer; Indocyanine green angiography; Limb salvage; Nutritional status; Perfusion assessment; Systemic optimization; Tissue oxygenation
Core Tip Intraoperative perfusion remains a key failure point in anterolateral thigh free-flap reconstruction for diabetic foot ulcers. Perfusion is not determined by microsurgical technique alone but reflects a systemic-regional-microcirculatory continuum, often confounded by diabetes-related macrovascular calcification and microvascular dysfunction. We emphasize standardizing indocyanine green fluorescence angiography and shifting from single intensity snapshots to time-intensity kinetics, interpreted alongside toe pressure/toe-brachial index, skin perfusion pressure, and transcutaneous oxygen tension. An actionable perioperative optimization bundle (glycemia, anemia, oxygen delivery, nutrition, monitoring) may improve flap reliability and limb salvage.
Publish Date 2026-06-11 11:23
Citation

Lu PY, Hao ZY, Xing GW, Zhang PF, Liu YS, Li WY, Xu MJ. Improving intraoperative perfusion reliability in anterolateral thigh free flap reconstruction for diabetic foot ulcers. World J Diabetes 2026; 17(6): 118576

URL https://www.wjgnet.com/1948-9358/full/v17/i6/118576.htm
DOI https://doi.org/10.4239/wjd.118576
Full Article (PDF) WJD-17-118576-with-cover.pdf
Manuscript File 118576_Auto_Edited-WJJ.docx
Answering Reviewers 118576-answering-reviewers.pdf
Audio Core Tip 118576-audio.mp3
Conflict-of-Interest Disclosure Form 118576-conflict-of-interest-statement.pdf
Copyright License Agreement 118576-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 118576-non-native-speakers.pdf
Peer-review Report 118576-peer-reviews.pdf
Scientific Misconduct Check 118576-scientific-misconduct-check.png
Scientific Editor Work List 118576-scientific-editor-work-list.pdf
CrossCheck Report 118576-crosscheck-report.pdf