| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Urinary cell-free DNA as a noninvasive liquid biopsy for hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Amy K Kim, Selena Y Lin, Hsin-Ni Liu, Surbhi Jain, Terence P Gade, Fwu-Shan Shieh, James Hamilton, Hie-Won Hann, Ting-Tsung Chang, Dmitry Goryunov, Zhili Wang and Ying-Hsiu Su |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
W81XWH-20-1-0605, 1K08CA237624-01A1 |
| National Institutes of Health |
5R44HG008700-03 |
| National Institutes of Health |
5R01CA202769-05, 1U01CA275648-01 |
| National Institutes of Health |
5R44CA165312-07, 1R43AI167169-01 |
|
| Corresponding Author |
Ying-Hsiu Su, /, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902, United States. ying-hsiu.su@bblumberg.org |
| Key Words |
Cell-free DNA; Hepatocellular carcinoma; Urine; Hepatocellular carcinoma mutation; Liquid biopsy |
| Core Tip |
Urinary cell-free DNA may serve as a simple, non-invasive tool for detecting liver cancer (hepatocellular carcinoma). In this study, we found that urine contains shorter, tumor-specific DNA fragments and unique genetic markers that help distinguish liver cancer patients from those with other chronic liver conditions. With similar accuracy to blood-based tests and the advantage of easier sample collection, urine cell-free DNA has the potential to improve liver cancer diagnosis and monitoring. |
| Publish Date |
2026-08-11 06:12 |
| Citation |
Kim AK, Lin SY, Liu HN, Jain S, Gade TP, Shieh FS, Hamilton J, Hann HW, Chang TT, Goryunov D, Wang Z, Su YH. Urinary cell-free DNA as a noninvasive liquid biopsy for hepatocellular carcinoma. World J Gastroenterol 2026; 32(33): 118587
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i33/118587.htm |
| DOI |
https://doi.org/10.3748/wjg.118587 |
