| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Risk factors and fatigue in difficult-to-treat Crohn's Disease: A cross-sectional study of a Chinese cohort
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi Wu, Zhi-Wei Huang, Zhi-Jun Cao, Ying Sun, Xin-Xian Zhao, Wen-Fang Xu, Sheng-Liang Chen, Yue Zhang and Shu-Liang Zhao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| “Science and Technology Innovation Action Plan” Medical Innovation Research Project of Shanghai Municipal Science and Technology Commission |
No. 22Y11907900 |
|
| Corresponding Author |
Shu-Liang Zhao, MD, PhD, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, State Key Laboratory for Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, No. 160 Pujian Road, Pudong New Area, Shanghai 200001, China. zhaosl@sjtu.edu.cn |
| Key Words |
Difficult-to-treat; Inflammatory bowel disease; Fatigue; Crohn’s disease; Cross-sectional study |
| Core Tip |
This study applied the international DTT-IBD criteria to a Chinese Crohn's disease (CD) cohort, revealing a high prevalence of difficult-to-treat CD (DTT-CD), primarily driven by complex perianal disease. We identified elevated serum IL-5 and IL-10 as independent risk factors for DTT-CD even after adjustment of disease activity, suggesting a distinct immune phenotype. Furthermore, DTT-CD was associated with significantly higher levels of patient-reported mental fatigue. |
| Publish Date |
2026-06-30 13:40 |
| Citation |
Wu Z, Huang ZW, Cao ZJ, Sun Y, Zhao XX, Xu WF, Chen SL, Zhang Y, Zhao SL. Risk factors and fatigue in difficult-to-treat Crohn's Disease: A cross-sectional study of a Chinese cohort. World J Gastroenterol 2026; 32(26): 118595
|
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i26/118595.htm |
| DOI |
https://doi.org/10.3748/wjg.118595 |
