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Articles Published Processes
8/5/2026 5:45:45 AM | Browse: 1 | Download: 0
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Received |
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2026-01-07 03:20 |
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Peer-Review Started |
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2026-01-07 03:21 |
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First Decision by Editorial Office Director |
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2026-02-26 07:34 |
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Return for Revision |
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2026-02-26 07:34 |
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Revised |
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2026-03-09 08:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-05-28 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-05-28 11:25 |
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Articles in Press |
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2026-05-28 11:25 |
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Edit the Manuscript by Language Editor |
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2026-06-02 19:16 |
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Typeset the Manuscript |
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2026-07-30 00:44 |
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Publish the Manuscript Online |
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2026-08-05 05:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Opinion Review |
| Article Title |
Pristimerin attenuates spasmolytic polypeptide-expressing metaplasia via p57 (Cdkn1c)-mediated glycolytic reprogramming: A metabolic avenue for gastric cancer prevention
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jun-Hao Han, Kong-Rui Lu, Min Zhang and Guo-Hua Gong |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guo-Hua Gong, Full Professor, Professor, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, No. 82 West College Road, Wenzhou 325035, Zhejiang Province, China. guohgong@wmu.edu.cn |
| Key Words |
Spasmolytic polypeptide-expressing metaplasia; Gastric precancerous lesion; Cdkn1c (p57); Pristimerin; Glycolytic reprogramming |
| Core Tip |
This opinion review discusses that the natural compound pristimerin reverses spasmolytic polypeptide-expressing metaplasia (SPEM), not only by alleviating high-dose tamoxifen-induced gastric mucosal damage and oxyntic atrophy but also by restoring parietal and chief cell lineages and suppressing abnormal proliferation. This work further identifies Cdkn1c (p57) as a metabolic checkpoint: P57 is downregulated in SPEM, upregulated by pristimerin, and required for its antiglycolytic and anti-SPEM effects in gastric organoids. |
| Publish Date |
2026-08-05 05:45 |
| Citation |
Han JH, Lu KR, Zhang M, Gong GH. Pristimerin attenuates spasmolytic polypeptide-expressing metaplasia via p57 (Cdkn1c)-mediated glycolytic reprogramming: A metabolic avenue for gastric cancer prevention. World J Gastroenterol 2026; 32(32): 118600
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i32/118600.htm |
| DOI |
https://doi.org/10.3748/wjg.118600 |
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