| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Yinchen Wuling San ameliorates high-fat diet-induced metabolic-associated fatty liver disease in rats by remodeling the gut microbiota
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Zhang, Jie Liu, Ai-Si Huang, Yu-Fei Wang, Jie Cao, Mu-Lan Li, Dan-Dan Shi, Yi-Lin Hu, Qin Deng, Piao Long and Bi-Chen Ai |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Major Scientific Research Project for High-level Talents in Health and Wellness of Hunan Province, China |
R2023130 |
| Scientific Research Project of Hunan Administration of Traditional Chinese Medicine, China |
D2022016 |
| Postgraduate Scientific Research and Innovation Project of Hunan Provincial Department of Education, China |
LXBZZ2024155 |
|
| Corresponding Author |
Bi-Chen Ai, Professor, School of Traditional Chinese Medicine, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha 410208, Hunan Province, China. 003626@hnucm.edu.cn |
| Key Words |
Metabolic-associated fatty liver disease; Yinchen Wuling San; Gut microbiota; Short-chain fatty acids; Gut-liver axis |
| Core Tip |
Yinchen Wuling San (YCWLS), a classical traditional Chinese medicine formula, alleviated the phenotypes of metabolic-associated fatty liver disease in rats fed a high-fat diet. This improvement was evidenced by enhanced liver histopathology, reduced levels of alanine aminotransferase and aspartate aminotransferase, and corrected dyslipidemia. Profiling of the 16S rRNA revealed that YCWLS reshaped the gut microbiota by significantly enriching Akkermansia and Lachnospiraceae while decreasing Firmicutes-associated taxa. Although there were only modest and non-significant increases in fecal short-chain fatty acids, the observed shift in microbiota was associated with metabolic improvements, suggesting a microbiota-linked mechanism through which YCWLS exerts its effects on metabolic-associated fatty liver disease. |
| Publish Date |
2026-06-26 09:50 |
| Citation |
Zhang Y, Liu J, Huang AS, Wang YF, Cao J, Li ML, Shi DD, Hu YL, Deng Q, Long P, Ai BC. Yinchen Wuling San ameliorates high-fat diet-induced metabolic-associated fatty liver disease in rats by remodeling the gut microbiota. World J Hepatol 2026; 18(6): 118607
|
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i6/118607.htm |
| DOI |
https://doi.org/10.4254/wjh.118607 |
